Zinc supplement effect on oxidative stress and inflammation markers in multiple myeloma patients undergo autologous hematopoietic stem cell transplantatio

Phase 2

Recruiting

• Conditions: Patients with multiple myeloma who are candidates for stem cell transplantation..; Multiple myeloma and malignant plasma cell neoplasms

• Registration Number: IRCT20211227053546N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 4 April 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Complete response to treatment
Lack of underlying disease
Do not get any infection in the last three months, including COVID19
Age range 40 to 60 years
Patients with a history of multiple myeloma

Exclusion Criteria

History of sensitivity to zinc oral supplement
Serum levels above 200 mg/dl
Patients who have taken oral supplements for three months before transplantation.
People's unwillingness to collaborate in the study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of genes(Nrf2-INrf2(Keap1)-SOD1,2-NOX1,2) expression. Timepoint: Before hematopoietic stem cell transplantation beginning and 15,30 days after transplantation. Method of measurement: In DNA extracted from peripheral blood mononuclear cells using Real-Time-PCR.;Determination of MDA-NO protein levels. Timepoint: Before hematopoietic stem cell transplantation beginning and 15,30 days after transplantation. Method of measurement: MDA assay by thiobarbituric acid method and NO assay by griess method.;Determination of TNF-a cytokine. Timepoint: Before hematopoietic stem cell transplantation beginning and 15,30 days after transplantation. Method of measurement: Assay of cytokines by ELISA method.