Efficacy and Safety of Fermented Ginseng Powder on Liver Function
- Conditions
- Fatty Liver, Nonalcoholic
- Interventions
- Dietary Supplement: fermented ginseng powderDietary Supplement: Placebo
- Registration Number
- NCT03260543
- Lead Sponsor
- Chonbuk National University Hospital
- Brief Summary
This study was conducted to investigate the effects of daily supplementation of fermented ginseng powder on improvement of Liver function.
- Detailed Description
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of fermented ginseng powder on improvement of Liver function. The investigators measured ALT(Alanine Transaminase) profiles, Liver function index, fatty liver grade, lipid metabolism index, total antioxidant capacity, imflammation index, and Multidimensional Fatigue Scale.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- Age 19-70 years with ALT 35-105 IU/L
-
Under antipsychotic drugs therapy within past 2 months
-
History of alcohol or substance abuse
-
Participation in any other clinical trials within past 2 months
-
Laboratory test by show the following results
- Serum Creatinine > 2.0 mg/dl
-
Pregnancy or breast feeding etc.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description fermented ginseng powder fermented ginseng powder tablets (2 tablets/day, 125 mg \& 500 mg/day) for 12 weeks. Placebo Placebo Placebo for 12 weeks.
- Primary Outcome Measures
Name Time Method Changes of ALT(Alanine Transaminase) Baseline and 12 weeks Changes of ALT were assessed before and after the intervention
- Secondary Outcome Measures
Name Time Method Changes of imflammation index Baseline and 12 weeks Changes of imflammation index were assessed before and after the intervention
Changes of Liver function index Baseline and 12 weeks Changes of AST were assessed before and after the intervention
Changes of total antioxidant capacity Baseline and 12 weeks Changes of total antioxidant capacity were assessed before and after the intervention
Changes of fatty liver grade Baseline and 12 weeks Changes of fatty liver grade were assessed before and after the intervention
Changes of Multidimensional Fatigue Scale Baseline and 12 weeks Changes of Multidimensional Fatigue Scale were assessed before and after the intervention
Changes of lipid metabolism index Baseline and 12 weeks Changes of lipid metabolism index were assessed before and after the intervention
Trial Locations
- Locations (1)
Clinical Trial Center for Functional Foods Chonbuk National University Hospital
🇰🇷Jeonju, Jeollabuk-do, Korea, Republic of