Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- 6 minute walk test
研究概览
简要总结
this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic stable heart failure patient with reduced ejection fraction (EF <40)
- •Age Above 18 years old
- •Both males and females
- •The ability to provide informed consent
排除标准
- •Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)
- •Acute myocardial infarction (MI), within 2 days
- •Ongoing unstable angina
- •Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
- •Active endocarditis
- •Symptomatic severe aortic stenosis
- •Decompensated heart failure
- •Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
- •Acute myocarditis or pericarditis
- •Acute aortic dissection
- •Physical disability that precludes safe and adequate testing or training
- •Known obstructive left main coronary artery stenosis
- •Hypertrophic obstructive cardiomyopathy with severe resting gradient
- •Recent stroke or transient ischemic attack
- •Mental impairment with limited ability to cooperate
- •Resting hypertension with systolic or diastolic blood pressures >200/110 mmHg
- •Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism
- •Acute decompensated heart failure NYHA class IV
研究组 & 干预措施
Low volume high intensity interval training
This group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week.
干预措施: low-volume high intensity interval training (Other)
Low volume high intensity interval training
This group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week.
干预措施: Standard medical treatment (Drug)
high volume high intensity interval training
In this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week
干预措施: High volume high intensity interval training (Other)
high volume high intensity interval training
In this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week
干预措施: Standard medical treatment (Drug)
control group
It includes 15 patients who will receive standard medical treatment only
干预措施: Standard medical treatment (Drug)
结局指标
主要结局
6 minute walk test
时间窗: at enrolment and at the end of treatment at 8 weeks
self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters
2D Echocardiographic parameters
时间窗: at enrollment and at the end of treatment at 8 weeks
Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml. Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio
次要结局
- Minnesota living with heart failure questionnaire (MLHFQ)(at enrollment and at the end of treatment at 8 weeks)
研究者
Aya Ibrahim Elshenawy Elshenawy
physical therapy specialist
Cairo University