A trial to compare the effectiveness of two different drugs for the treatment of children with nephrotic syndrome.
Phase 3
Completed
- Conditions
- Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
- Registration Number
- CTRI/2018/07/015143
- Lead Sponsor
- Jawaharlal Nehru Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Inclusion Criteria
1. Two or more relapses in 6 months while on alternate day levamisole with tapering alternate day prednisolone therapy, or
2. If the prednisolone threshold to maintain remission exceeds 0.7 mg/kg on alternate days or,
3. Patients have significant steroid toxicity (cushingoid with hypertension, ocular toxicity such as cataract, glaucoma or an episode of serious life threatening infection).
Exclusion Criteria
1.Age at onset of nephrotic syndrome less than 1 year or more than 10 year.
2. History of use of alternative treatment other than alternate day levamisole.
3. Biopsy showing pathology other than MCNS.
4. Secondary nephrotic syndrome.
5. Late steroid resistance.
6. Residing >100 km from centre or unwilling to follow up.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method