Hesperidin and Diosmin Effect on Metabolic Syndrome
- Conditions
- Metabolic Syndrome and Diabetic Neuropathy
- Interventions
- Dietary Supplement: dietary supplement flavonoids
- Registration Number
- NCT05243238
- Lead Sponsor
- Beni-Suef University
- Brief Summary
The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 129
Type 2 diabetes adult patients who meet metabolic syndrome criteria and with diabetic neuropathy
patients without any parameter of inclusion criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Hesperidin group dietary supplement flavonoids - Diosmin dietary supplement flavonoids - Hesperidin and diosmin dietary supplement flavonoids -
- Primary Outcome Measures
Name Time Method MNSI score for neuropathy 12 weeks neuropathy improvement if MNSI score decreased
metabolic syndrome components 12 weeks TGs, mg/dl
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University
🇪🇬Fayoum, Egypt