ICU-Acquired Respiratory muscle Dysfunction (the ICARD study)
- Conditions
- Diaphragm muscle weaknessExpiratory muscle weaknessVentilator induced expiratory muscle dysfunctionVentilator-induced diaphragm dysfunction10028302
- Registration Number
- NL-OMON51396
- Lead Sponsor
- Amsterdam UMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 110
Inclusion Criteria
1. mechanically ventilated patients planned for a laparotomy for suspected or
proven intra-abdominal sepsis or for other reasons such as trauma, abdominal
haemorrhage, vascular surgery. (50 patients)
2. Patients scheduled for elective thoracotomy or lobectomy for removal of a
pulmonary tumor (30 patients).
3. Patients scheduled for elective abdominal surgery (30 patients)
-Age: >18 years
-Informed consent
Exclusion Criteria
COPD (GOLD 3-4) or CHF (NYHA 3-4)
-Neuromuscular disease
-Chronic metabolic disease
-Pulmonary hypertension
-Chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months)
-Drugs known to alter muscle structure and function
->10% weight loss within last 6 months
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Contractile force of single respiratory muscle fibers.</p><br>
- Secondary Outcome Measures
Name Time Method