Investigating ovulation stimulation with the combination of GnRH agonist and HCG in polycystic ovary syndrome
Phase 3
Recruiting
- Conditions
- Infertility.Female infertility
- Registration Number
- IRCT20180708040381N4
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
Selection of women with PCOS based on ESHRE ASRM Rotterdam criteria
Stimulation with GnRH antagonist protocol
Age 20-38 years
E2 concentration > 2500 international units on the trigger day
Body mass index > 18 and < 30
Having an indication for IVF or ICSI
Willingness to participate in the study
Exclusion Criteria
severe cause of male infertility
Uterine anomalies
Severe endometriosis
metabolic disease (e.g. metabolic syndrome)
Age above 38 and below 20 years
Patients with hypogonadism, hypogonadotropism
Patients with underlying diseases such as thyroid, hyperprolactinemia, Cushing's syndrome, ovarian and adrenal tumors, diabetes, etc.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of mature oocytes. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Trans vaginal ultrasound.;Number of retrieved oocytes. Timepoint: 34-36 hours after decapeptil injection. Method of measurement: Trans vaginal ultrasound.;The number of blastocysts. Timepoint: Two weeks after administration of Decapeptil. Method of measurement: Abdominal ultrasound.
- Secondary Outcome Measures
Name Time Method Positive pregnancy test. Timepoint: 4 weeks after IVF. Method of measurement: Beta HCG test.