Sensory Profiles as Predictors of Central Sensitization in Low Back Pain: A Prospective Cohort Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Central Sensitization Inventory score
研究概览
简要总结
A longitudinal observational cohort study to investigate the value of prognostic factors, here sensory profiles , and others, in the development of central sensitization in the low back pain population. A type 2 prognostic factor research following the PROGRESS framework. Sensory profiles are identified a prognostic factors which can predict the development of central sensitization in the low back pain population.
详细描述
After performing an univariable linear regression analyses the regression model predicts the dependent variable, central sensitization, significantly, and the models are significant prediction factors of the development of central sensitization. In unadjusted analyses, all four sensory profiles were significantly associated with the development of central sensitization (P<0.001).
After adjusting for pain, disability, age, and duration of low back pain, baseline sensory profiles remained significant predictors of central sensitization. On the other hand, all other predictor variables did not contribute to the prediction of central sensitization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute low back pain (< 6 weeks)
- •with or without radiating pain
- •aged 18 to 60 years
- •a pain-free episode for at least 3 months before the onset of their current back pain
- •read and understand the Dutch language.
排除标准
- •previous lumbar spinal surgery
- •lumbar radicular syndrome
- •specific cause of low back pain
- •lumbar spinal stenosis
- •current malignancy
- •spondyloarthropathy
- •osteoporosis
- •spondylolisthesis
- •major trauma
- •infection
- •systemic disease.
结局指标
主要结局
Central Sensitization Inventory score
时间窗: 12 weeks
The validated questionnaire Central Sensitization Inventory which scores on a 5 point scale ranging from 0-100. A higher score indicated a higher degree of central sensitization.
Adolescent/Adult Sensory Profile score
时间窗: 0 weeks
Adolescent/Adult Sensory Profile measures 4 sensory profiles (sensation avoiding, sensation sensitive, sensation seeking, low registration) on ad 5 point scale, and is validated in the low back pain population. Scores range from 15-60 points per variable. A higher score means a higher degree of sensitivity for the specific sensory profile.
次要结局
- Numeric Pain Rating Scale score(Baseline (0 weeks))
- Pain Disability Index score(Baseline (0 weeks))
- age(Baseline (0 weeks))
- duration of low back pain(Baseline (0 weeks))
研究者
Pieter Graper
Principal Investigator
Vrije Universiteit Brussel