comparision of different protamine to heparin dosing strategies in cardiac surgeries requiring cardio pulmonary bypass
Phase 1
- Conditions
- Health Condition 1: I20-I25- Ischemic heart diseases
- Registration Number
- CTRI/2021/02/031467
- Lead Sponsor
- Balabhadra Sai Priyanka
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
patients undergoing cardiac surgery requiring cardiopulmonary bypass
Exclusion Criteria
known defects of haemostatic system
thrombocytopenia
surgeries requiring dhca
patients who didnt stop clopidogrel 5 days prior to surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to compare ACT after 0.75:1 protamine to heparin ratio with 1:1 protamine to heparin ratioTimepoint: 1.BASELINE ACT at the start of surgery <br/ ><br>2.ACT after giving heparin 4mg/kg <br/ ><br>3.ACT immediately after reversal from protamine <br/ ><br>4.ACT after 30 min after reversal from protamine
- Secondary Outcome Measures
Name Time Method 1.To study protamine adverse reactions. <br/ ><br>2.To compare peri-operative blood loss and utilization of blood products in both groups. <br/ ><br>3.To study effect of temperature on dose requirements of protamine. <br/ ><br>Timepoint: 1.Bleed from mediastinal drains will be quantified for 3 hours. <br/ ><br>2.Haemoglobin levels will be monitored for 3 hours. <br/ ><br>3.Coagulation profile after 4 hours of surgery. <br/ ><br>5.Transfusion requirements in first 48 hours after surgery <br/ ><br>