A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)
- Conditions
- Early Alzheimer´s Disease
- Interventions
- Drug: Placebo (semaglutide)
- Registration Number
- NCT04777409
- Lead Sponsor
- Novo Nordisk A/S
- Brief Summary
This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease.
Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance.
The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken.
Participants must have a study partner, who is willing to take part in the study.
Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period.
A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1840
- Male or female, aged 55-85 years (both inclusive) at the time of signing informed consent.
- MCI (mild cognitive impairment) or mild dementia of the Alzheimer's type according to the NIA-AA (National Institute of Aging-Alzheimer's Association) 2018 criteria.
- CDR (Clinical Dementia Rating) global score of 0.5 and CDR of 0.5 or more in at least one of the three instrumental activities of daily living categories (personal care, home & hobbies, community affairs) Or CDR global score of 1.0
- RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) delayed memory index score of below or equal to (≤) 85
- MMSE (Mini-Mental State Examination) greater than or equal to (≥) 22
- Amyloid positivity established with either amyloid PET (positron emission tomography), CSF (cerebrospinal fluid) Aβ1-42 or CSF Aβ1-42/Aβ1-40.
- If receiving an approved Alzheimer's disease treatment (such as acetylcholinesterase inhibitors, memantine or aducanumab) the dose must have been stable for at least 3 months prior to screening and should not be changed during the study unless medically necessary.
- Brain Magnetic resonance imaging (MRI) (or Computed Tomography (CT)) scan suggestive of clinically significant structural CNS (central nervous system) disease confirmed by central read (e.g. cerebral large-vessel disease [large vessel (cortical) infarcts greater than (>) 10 milimeter (mm) in diameter], prior macro-haemorrhage [greater than 1 cubic centimetre (cm^3)], cerebral vascular malformations, cortical hemosiderosis, intracranial aneurism(s), intracranial tumours, changes suggestive of normal pressure hydrocephalus).
- Brain MRI (or CT) scan suggestive of strategic infarcts defined as bilateral thalamic lacunar infarcts and singular paramedian thalamic infarcts confirmed by central read.
- Evidence of a relevant neurological disorder other than mild cognitive impairment (MCI) or mild dementia of the Alzheimer's type at screening, including but not limited to Parkinson's disease, Lewy body disease, frontotemporal dementia of any type, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, systemic lupus erythematosus, progressive supranuclear palsy, neurosyphilis, human immunodeficiency virus (HIV), learning disability, intellectual disability, hypoxic cerebral damage, or significant head trauma with loss of consciousness that led to persistent cognitive deficits.
- Evidence of a clinically relevant or unstable psychiatric disorder, based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, including schizophrenia or other psychotic disorder, or bipolar disorder. A participant with a history of major depression who has not had an episode in the last 24 months before the day of screening and is considered in remission or whose depression is controlled with treatment can be included in the study per investigator's judgement.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oral semaglutide Semaglutide Participants are given oral semaglutide once daily Placebo (semaglutide) Placebo (semaglutide) Participants are given oral placebo once daily
- Primary Outcome Measures
Name Time Method Change in the Clinical Dementia Rating - Sum of Boxes (CDR-SB) score From baseline (week 0) to week 104 Score on scale (0 to 18)
Measures the impact of cognitive decline on daily function using the following six domains commonly affected in Alzheimer's disease:
* Cognitive domains: memory, orientation, and judgement and problem solving
* Function domains: community affairs, home and hobbies, and personal care Based on clinical information obtained from the subject and informant, an individual box score ranging from 0 to 3 is determined that represents "none" to "severe" impairment for each of the six domains.
The CDR-Sum of Boxes (CDR-SB) score will be derived by adding the individual scores of the six domains at a given time point. The total CDR-SB score ranges from 0 to 18 with higher scores representing greater impairment.
- Secondary Outcome Measures
Name Time Method Main Phase: Change in the 24-item Alzheimer's Disease Cooperative Study Activities of Daily Living Scale for Mild Cognitive Impairment (ADCS-ADL-MCI) score From baseline (week 0) to week 104 Score on scale (0 to 53). An interview-based assessment of information provided by the study partner (informant). The total scores based on 18 items on the scale range from 0 to 53 with lower scores representing greater impairment.
Extension phase: Change in the ADCS-ADL-MCI score From baseline (week 0) to week 156 Score on scale (0 to 53) An interview-based assessment of information provided by the study partner (informant). The total scores based on 18 items on the scale range from 0 to 53 with lower scores representing greater impairment.
Main Phase: Time to progression to Clinical Dementia Rating (CDR) global score greater than or equal to (≥)1.0 among patients with CDR global score equal to (=) 0.5 at baseline From baseline (week 0) up to week 156 Week(s)
Extension Phase: Time to progression to Clinical Dementia Rating (CDR) global score greater than or equal to (≥)1.0 among patients with CDR global score equal to (=) 0.5 at baseline From baseline (week 0) to week 156 Week(s)
Main Phase: Change in the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog-13) score From baseline (week 0) to week 104 Score on scale (0 to 85) Measures the severity of cognitive impairment in various domains including memory, language, orientation, praxis and executive function. The total scores on the scale range from 0 to 85 with higher scores representing greater impairment.
Extension Phase: Change in the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog-13) score From baseline (week 0) to week 156 Score on scale (0 to 85) Measures the severity of cognitive impairment in various domains including memory, language, orientation, praxis and executive function. The total scores on the scale range from 0 to 85 with higher scores representing greater impairment.
Main Phase: Change in the Montreal Cognitive Assessment (MoCA) score From baseline (week 0) to week 104 Score on scale (0 to 30) The assessment includes 8 domains of cognitive function with total scores ranging from 0 to 30 and lower scores indicating greater impairment.
Extension Phase: Change in the Montreal Cognitive Assessment (MoCA) score From baseline (week 0) to week 156 Score on scale (0 to 30) The assessment includes 8 domains of cognitive function with total scores ranging from 0 to 30 and lower scores indicating greater impairment.
Main Phase: Change in the Alzheimer's Disease Composite Score (ADCOMS) From baseline (week 0) to week 104 Score on scale (0 to 1.97) The ADCOMS is a composite clinical outcome comprising 4 items from the ADAS-Cog-13, 2 items from the MMSE and all 6 items from the CDR-SB.32 The total scores on the scale range from 0 to 1.97 with higher scores indicating greater impairment.
Extension Phase: Change in the Alzheimer's Disease Composite Score (ADCOMS) From baseline (week 0) to week 156 Score on scale (0 to 1.97) The ADCOMS is a composite clinical outcome comprising 4 items from the ADAS-Cog-13, 2 items from the MMSE and all 6 items from the CDR-SB.32 The total scores on the scale range from 0 to 1.97 with higher scores indicating greater impairment.
Main Phase: Change in the Mini-Mental State Examination (MMSE) score From baseline (week 0) to week 104 Score on scale (0 to 30) The MMSE measures orientation, attention, memory, language and visuo-spatial function. The total scores on the scale range from 0 to 30 with lower scores indicating greater impairment.
Extension Phase: Change in the Mini-Mental State Examination (MMSE) score From baseline (week 0) to week 156 Score on scale (0 to 30) The MMSE measures orientation, attention, memory, language and visuo-spatial function. The total scores on the scale range from 0 to 30 with lower scores indicating greater impairment.
Main Phase: Time to progression in disease stage based on CDR global score From baseline (week 0) up to week 156 Week(s)
Extension Phase: Time to progression in disease stage based on CDR global score From baseline (week 0) to week 156 Week(s)
Main Phase: Change in the composite Z-score based on the three outcome measures CDR-SB, ADCS-ADL-MCI, and ADAS-Cog-13 From baseline (week 0) to week 104 Score
Extension Phase: Change in the composite Z-score based on the three outcome measures CDR-SB, ADCS-ADL-MCI, and ADAS-Cog-13 From baseline (week 0) to week 156 Score
Main Phase: Change in the 10-item Neuropsychiatric Inventory (NPI) score From baseline (week 0) to week 104 104 Score on scale (0 to 120) The 10-item scale assesses symptoms including delusions, hallucinations, agitation/aggression, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability/lability and aberrant motor activity. For each domain the frequency (4-point scale) and severity (3-point scale) of symptoms is reported. The score for each domain is calculated by multiplying the frequency and severity score. The total 10-item NPI score is 0 to 120 with higher scores indicating a greater symptomatology.
Extension Phase: Change in the 10-item Neuropsychiatric Inventory (NPI) score From baseline (week 0) to week 156 104 Score on scale (0 to 120) The 10-item scale assesses symptoms including delusions, hallucinations, agitation/aggression, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability/lability and aberrant motor activity. For each domain the frequency (4-point scale) and severity (3-point scale) of symptoms is reported. The score for each domain is calculated by multiplying the frequency and severity score. The total 10-item NPI score is 0 to 120 with higher scores indicating a greater symptomatology.
Main Phase: Change in high sensitivity C-reactive protein level From baseline (week 0) to week 104 Ratio to baseline
Extension Phase: Change in high sensitivity C-reactive protein level From baseline (week 0) to week 156 Ratio to baseline
Main Phase: Number of treatment emergent adverse events (TEAEs) From baseline (week 0) up to week 156 Number of events
Extension Phase: Number of treatment emergent adverse events (TEAEs) From baseline (week 0) to week 156 Number of events
Main Phase: Time to first occurrence of major adverse cardiovascular event (MACE) comprising non-fatal myocardial infarction, non-fatal stroke and allcause death From baseline (week 0) to week 104 Week(s)
Extension Phase: Time to first occurrence of major adverse cardiovascular event (MACE) comprising non-fatal myocardial infarction, non-fatal stroke and allcause death From baseline (week 0) to week 156 Week(s)
Main Phase: Time to first occurrence of stroke From baseline (week 0) to week 104 Weeks
Extension Phase: Time to first occurrence of stroke From baseline (week 0) to week 156 Weeks
Main Phase: Change in the EQ-5D-5L (proxy version) index score From baseline (week 0) to week 104 Score The EQ-5D-5L descriptive system comprises mobility, self-care, usual activities, pain/discomfort and anxiety/depression with five response levels each (no problems, slight problems, moderate problems, severe problems, unable to /extreme problems). The EQ-5D-5L proxy version 1 (the study partner is asked to rate how he/she \[the proxy\] would rate the subject´s health) will be used in this trial.
Extension Phase: Change in the EQ-5D-5L (proxy version) index score From baseline (week 0) to week 156 Score The EQ-5D-5L descriptive system comprises mobility, self-care, usual activities, pain/discomfort and anxiety/depression with five response levels each (no problems, slight problems, moderate problems, severe problems, unable to /extreme problems). The EQ-5D-5L proxy version 1 (the study partner is asked to rate how he/she \[the proxy\] would rate the subject´s health) will be used in this trial.
Extension phase: Change in the CDR-SB score From baseline (week 0) to week 156 Score on scale (0 to 18)
Measures the impact of cognitive decline on daily function using the following six domains commonly affected in Alzheimer's disease:
* Cognitive domains: memory, orientation, and judgement and problem solving
* Function domains: community affairs, home and hobbies, and personal care Based on clinical information obtained from the subject and informant, an individual box score ranging from 0 to 3 is determined that represents "none" to "severe" impairment for each of the six domains.
The CDR-Sum of Boxes (CDR-SB) score will be derived by adding the individual scores of the six domains at a given time point. The total CDR-SB score ranges from 0 to 18 with higher scores representing greater impairment.
Trial Locations
- Locations (384)
Osrodek Alzheimerowski Sp. z o.o.
🇵🇱Scinawa, Poland
Centrum Medyczne SENIOR
🇵🇱Sopot, Poland
Centrum Medyczne Neuro Protect
🇵🇱Warszawa, Poland
NZOZ Wrocławskie Centrum Alzheimerowskie
🇵🇱Wroclaw, Poland
Chang Gung Memorial Hospital Linkou
🇨🇳Taoyuan City, Taiwan
Hacettepe University Medical Faculty Hospital
🇹🇷Altindag/Ankara, Turkey
Odesa Regional Medical Center for Mental Health
🇺🇦Odesa, Ukraine
Dementia Research Unit,
🇬🇧Crowborough, United Kingdom
Dementia Research Unit
🇬🇧Crowborough, United Kingdom
Neuropsychiatrie
🇨🇿Praha 6 Dejvice, Czechia
Vestra Clinics s.r.o.
🇨🇿Rychnov nad Kneznou, Czechia
Aarhus Universitetshospital
🇩🇰Aarhus N, Denmark
Rigshospitalet - afsnit 8015
🇩🇰København Ø, Denmark
Sjællands Universitetshospital_Roskilde
🇩🇰Roskilde, Denmark
CRST Helsinki
🇫🇮Helsinki, Finland
Aivotutkimusyksikkö
🇫🇮Kuopio, Finland
CRST Turku
🇫🇮Turku, Finland
P-one Clinic
🇯🇵Hachioji-shi, Tokyo, Japan
National Hospital Organization Tenryu Hospital
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Hyogo Brain and Heart Center
🇯🇵Himeji-city, Hyogo, Japan
Tsukazaki Hospital
🇯🇵Himeji-shi, Hyogo, Japan
Himeji Central Hospital Clinic
🇯🇵Himeji-shi, Hyogo, Japan
Hatsuta Neurology Clinic
🇯🇵Hirakata-Shi,Osaka, Japan
Imon Yukari Neurology Clinic
🇯🇵Hiroshima-shi, Hiroshima, Japan
NZOZ NEURO - KARD Ilkowski i Partnerzy Sp. Part. Lekarzy
🇵🇱Poznan, Poland
Fundación ACE
🇪🇸Barcelona, Spain
Hospital 12 de Octubre
🇪🇸Madrid, Spain
Hospital Quirón
🇪🇸Pozuelo de Alarcon, Spain
Hospital Universitari General de Catalunya
🇪🇸Sant Cugat del Vallès, Spain
Instituto Privado Kremer
🇦🇷Córdoba, Argentina
Fundación Scherbovsky
🇦🇷Mendoza, Argentina
MMA, MHAT-Sofia, Neurology clinic
🇧🇬Sofia, Bulgaria
AD71 s.r.o.
🇨🇿Praha 10, Czechia
Centre de la Mémoire
🇨🇭Genève, Switzerland
Centre Leenaards de la mémoire CHUV
🇨🇭Lausanne, Switzerland
K2 Medical Research, Maitland
🇺🇸Maitland, Florida, United States
IMIC, Inc- Medical Research
🇺🇸Miami, Florida, United States
The Neurology Research Group
🇺🇸Miami, Florida, United States
Visionary Inv Ntwrk_Miami
🇺🇸Miami, Florida, United States
Indago Research & Health Center Inc.
🇺🇸Hialeah, Florida, United States
Premier Clin Res Inst, Inc.
🇺🇸Miami, Florida, United States
Hlth Cr Family Rehab & Res Ctr
🇺🇸Miami, Florida, United States
Galiz Research
🇺🇸Hialeah, Florida, United States
Kishiro Mental Clinic
🇯🇵Kawasaki-shi , Kanagawa, Japan
Premier Clinical Research Institute, Inc.
🇺🇸Miami, Florida, United States
Central Miami Medical Institute
🇺🇸Miami, Florida, United States
Novel Clinical Research Center, LLC
🇺🇸Miami, Florida, United States
Koukan Clinic
🇯🇵Kawasaki-shi, Kanagawa, Japan
Banner Alzheimer's Institute
🇺🇸Phoenix, Arizona, United States
Banner Sun Health Research Institute
🇺🇸Sun City, Arizona, United States
Advanced Research Center, Inc.
🇺🇸Anaheim, California, United States
Torrance Clin Res Inst, Inc.
🇺🇸Lomita, California, United States
ASCLEPES Research Centers,
🇺🇸Long Beach, California, United States
Well Care Medical Center
🇺🇸Panorama City, California, United States
Cedars-Sinai Medical Center
🇺🇸Pasadena, California, United States
Sharp Neurocog Res Ctr
🇺🇸San Diego, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
Calfornia Neurosc Resrch Med
🇺🇸Sherman Oaks, California, United States
Mountain Neurological Research Center, Inc.
🇺🇸Basalt, Colorado, United States
Denver Neurological Research
🇺🇸Denver, Colorado, United States
Mile High Research Center
🇺🇸Denver, Colorado, United States
Nuvance Health, Associtd Neuro
🇺🇸Danbury, Connecticut, United States
Research Center for Clinical Studies, Inc
🇺🇸Norwalk, Connecticut, United States
JEM Research Institute
🇺🇸Atlantis, Florida, United States
Visionary Investigators Network
🇺🇸Aventura, Florida, United States
Brain Matters Research
🇺🇸Delray Beach, Florida, United States
Neuropsychiatric Research Cent
🇺🇸Fort Myers, Florida, United States
Finlay Medical Research Group
🇺🇸Greenacres City, Florida, United States
Aqualane Clinical Research
🇺🇸Naples, Florida, United States
Suncoast Clinical Research, Inc._New Port Richey
🇺🇸New Port Richey, Florida, United States
K2 Medical Research - Winter Garden
🇺🇸Ocoee, Florida, United States
Advanced Research Consultants, Inc.
🇺🇸Palm Beach Gardens, Florida, United States
Intercoastal Medical Group
🇺🇸Sarasota, Florida, United States
Brain Matters Resrch Kane Cntr
🇺🇸Stuart, Florida, United States
Axiom Clinical Research of Florida
🇺🇸Tampa, Florida, United States
Stedman Clinical Trials LLC
🇺🇸Tampa, Florida, United States
Conquest Research
🇺🇸Winter Park, Florida, United States
iResearch Atlanta, LLC
🇺🇸Decatur, Georgia, United States
Hawaii Neuroscience, Memory Disorders Center
🇺🇸Honolulu, Hawaii, United States
Velocity Clinical Research, Meridian
🇺🇸Meridian, Idaho, United States
Velocity Clinical Research
🇺🇸Meridian, Idaho, United States
Josephson Wallack Munshower
🇺🇸Indianapolis, Indiana, United States
Cotton-O'Neil Clinical Research Center
🇺🇸Topeka, Kansas, United States
University of Kentucky_Lexington_0
🇺🇸Lexington, Kentucky, United States
Northern Light Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
HealthPartners Center for Memory and Aging
🇺🇸Saint Paul, Minnesota, United States
Hattiesburg Clinic
🇺🇸Hattiesburg, Mississippi, United States
Wr-Crcn, Llc
🇺🇸Las Vegas, Nevada, United States
Patient First MD,clinical Trials
🇺🇸Middletown, New Jersey, United States
Advanced Memory Research Institute of NJ
🇺🇸Toms River, New Jersey, United States
Neurological Assoc Long Island
🇺🇸Lake Success, New York, United States
Feinstein Institute for Medical Research
🇺🇸Manhasset, New York, United States
Richmond Behavioral Associates
🇺🇸Staten Island, New York, United States
SUNY Upstate Medical University_Syracuse
🇺🇸Syracuse, New York, United States
New Hope Clinical Research
🇺🇸Charlotte, North Carolina, United States
AMC Research, LLC
🇺🇸Matthews, North Carolina, United States
NeuroScience Research Center, LLC
🇺🇸Canton, Ohio, United States
Insight Clinical Trials LLC
🇺🇸Independence, Ohio, United States
Cleveland Clinic_Lakewood
🇺🇸Lakewood, Ohio, United States
Central States Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Summit Research Network Oregon Inc.
🇺🇸Portland, Oregon, United States
Neural Net Research, LLC
🇺🇸Portland, Oregon, United States
Coastal Neurology
🇺🇸Port Royal, South Carolina, United States
Palmetto Clinical Research
🇺🇸Summerville, South Carolina, United States
Genesis Neuroscience Clinic
🇺🇸Knoxville, Tennessee, United States
Vanderbilt Medical Center
🇺🇸Nashville, Tennessee, United States
Texas Diabetes & Endocrinology
🇺🇸Austin, Texas, United States
Balyor College of Medicine
🇺🇸Houston, Texas, United States
Univ Of Texas Hlth Science Cntr
🇺🇸Houston, Texas, United States
Mt. Olympus Medical Research
🇺🇸Katy, Texas, United States
Glenn Biggs Inst-Alzhm Neuro
🇺🇸San Antonio, Texas, United States
Shirzadi Shahin, MD
🇺🇸Sugar Land, Texas, United States
Memory Clinic, Inc
🇺🇸Bennington, Vermont, United States
Integrated Neurology Services
🇺🇸Falls Church, Virginia, United States
Booth Gardner Parkinson's Cre
🇺🇸Kirkland, Washington, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
Instituto Medico Especializado_Capital Federal
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Metabolicas (IDIM)
🇦🇷Buenos Aires, Argentina
Hospital Italiano
🇦🇷Buenos Aires, Argentina
Clínica Nuestra Señora de las Nieves
🇦🇷Caba, Argentina
FLENI
🇦🇷Caba, Argentina
St Vincent's Hospital
🇦🇺Darlinghurst, New South Wales, Australia
Geriatriskt centrum, Umeå
🇸🇪Umeå, Sweden
HammondCare Greenwich
🇦🇺Greenwich, New South Wales, Australia
Southern Neurology
🇦🇺Kogarah, New South Wales, Australia
KaRa Institute of Neurological Disease Pty Ltd
🇦🇺Macquarie Park, New South Wales, Australia
Hunter New England Local Health District - Neuropsychiatry
🇦🇺Waratah, New South Wales, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
Medical and Cognitive Research Unit - Austin Health
🇦🇺Ivanhoe, Victoria, Australia
HammondCare
🇦🇺Malvern, Victoria, Australia
Alzheimer's Research Australia
🇦🇺Nedlands, Western Australia, Australia
Australian Alzheimer's Research Foundation Incorporated
🇦🇺Nedlands, Western Australia, Australia
LKH-Univ. Kliniken Innsbruck
🇦🇹Innsbruck, Austria
Medizinische Univ. Innsbruck
🇦🇹Innsbruck, Austria
Univ. Klinik für Neurologie
🇦🇹Salzburg, Austria
Medizinische Universität Wien
🇦🇹Wien, Austria
UZA - UZ Antwerpen - Department of Neurology
🇧🇪Edegem, Belgium
UZ Gent - Neurologie
🇧🇪Gent, Belgium
AZ Groeninge - Kortrijk - Neurologie
🇧🇪Kortrijk, Belgium
UZ Leuven - Geheugenkliniek
🇧🇪Leuven, Belgium
Clinique CHC MontLégia - Service Neurologie
🇧🇪Liège, Belgium
L2 IP Instituto de Pesquisas Clinicas Ltda
🇧🇷Brasília, Distrito Federal, Brazil
Instituto de Neurologia de Curitiba
🇧🇷Curitiba, Parana, Brazil
Clinica Clinilive Ltda
🇧🇷Maringa, Parana, Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
CPQuali Pesquisa Clínica Ltda
🇧🇷São Paulo, Sao Paulo, Brazil
BR Trials - Ensaios Clínicos e Consultoria Ltda.
🇧🇷São Paulo, Sao Paulo, Brazil
Centro de Psiquiatria Sandra Rushel
🇧🇷Rio de Janeiro, Brazil
"MHATNP "Sv. Naum"" EAD
🇧🇬Sofia, Bulgaria
DCC Sv. Vrach and Sv. Sv. Kuzma and Damyan
🇧🇬Sofia, Bulgaria
"UMHAT "Aleksandrovska", Neurology clinic
🇧🇬Sofia, Bulgaria
Spitalzentrum Biel
🇨🇭Biel-Bienne, Switzerland
OCT Research ULC (dba Okanagan Clinical Trials)
🇨🇦Kelowna, British Columbia, Canada
Island Health (Research and Capacity Building)
🇨🇦Victoria, British Columbia, Canada
Medical Arts Health Research Group
🇨🇦West Vancouver, British Columbia, Canada
True North Clinical Research - Halifax
🇨🇦Halifax, Nova Scotia, Canada
True North Clinical Research - New Minas
🇨🇦New Minas, Nova Scotia, Canada
Recherches Neuro-Hippocampe Inc
🇨🇦Ottowa, Ontario, Canada
Kawartha Centre Redefining Healthy Aging
🇨🇦Peterborough, Ontario, Canada
Memory Program
🇨🇦Toronto, Ontario, Canada
Centricity Research LMC
🇨🇦Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
University Health Network
🇨🇦Toronto, Ontario, Canada
MoCA Research Innovation Inc
🇨🇦Greenfield-Park, Quebec, Canada
Douglas Hosp Res Ctr
🇨🇦Montréal, Quebec, Canada
CHU de Quebec-Universite Laval
🇨🇦Québec, Quebec, Canada
Diex Recherche Sherbrooke Inc.
🇨🇦Sherbrooke, Quebec, Canada
Beijing Chao-Yang Hospital, Capital Medical University-Neuro
🇨🇳Beijing, Beijing, China
Beijing Friendship Hospital, Capital Medical University-Neur
🇨🇳Beijing, Beijing, China
Beijing Hospital-Neurology
🇨🇳Beijing, Beijing, China
Xuanwu Hospital Capital Medical University-Neurology
🇨🇳Beijing, Beijing, China
Beijing Tiantan Hospital, Capital Medical University-Neurology Center
🇨🇳Beijing, Beijing, China
Beijing An Ding Hospital Capital Medical University-Geriatric Psychiatry
🇨🇳Beijing, Beijing, China
Peking University Sixth Hospital-Geriatrics
🇨🇳Beijing, Beijing, China
Beijing Huilongguan Hospital-Geriatrics
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital-Neurology
🇨🇳Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University-Geriatrics
🇨🇳Chongqing, Chongqing, China
Fujian Medical University Union Hospital-Neurology
🇨🇳Fuzhou, Fujian, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Neurol
🇨🇳Guangzhou, Guangdong, China
Guangzhou First People's Hospital-Neurology
🇨🇳Guangzhou, Guangdong, China
The Second affiliated hospital of Guangzhou Medical University-Neurology
🇨🇳Guangzhou, Guangdong, China
Henan Provincial People's Hospital-Neurology
🇨🇳Zhengzhou, Henan, China
Xiangya Hospital Central South University-Neurology
🇨🇳Changsha, Hunan, China
Baogang Hospital of Inner Mongolia-Neurology
🇨🇳Baotou, Inner Mongolia, China
Nanjing Brain Hospital-Neurology
🇨🇳Nanjing, Jiangsu, China
Nanjing Drum Tower Hospital-Neurology
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital Southeast University-Nephrology
🇨🇳Nanjing, Jiangsu, China
Wuxi Mental Health Center-Psychiatry
🇨🇳Wuxi, Jiangsu, China
Wuxi Mental Health Center
🇨🇳Wuxi, Jiangsu, China
Northern Jiangsu People's Hospital-Neurology
🇨🇳Yangzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University-Neurol
🇨🇳Nanchang, Jiangxi, China
The First Bethune Hospital of Jilin University, Neurology
🇨🇳Changchun, Jilin, China
Qinghai Provincial People's Hospital-Geriatrics
🇨🇳Xining, Qinghai, China
Huashan Hospital Fudan University-Neurology
🇨🇳Shanghai, Shanghai, China
Dongfang Hospital Affiliated to Shanghai Tongji University-Neurology
🇨🇳Shanghai, Shanghai, China
Shanghai 6th People's Hosp. Affili. to SHJT Univer-Neurology
🇨🇳Shanghai, Shanghai, China
Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Neurology
🇨🇳Shanghai, Shanghai, China
West China Hospital Sichuan University-Mental health center
🇨🇳Chengdu, Sichuan, China
General Hospital of Tianjin Medical University-Neurology
🇨🇳Tianjin, Tianjin, China
Tianjin Huanhu Hospital-Neurology
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital of Zhejiang University School of Medicine-Neurology
🇨🇳Hangzhou, Zhejiang, China
Poliklinika Solmed
🇭🇷Zagreb, Grad Zagreb, Croatia
KBC Zagreb, Klinika za neurologiju
🇭🇷Zagreb, Croatia
Poliklinika Bonifarm
🇭🇷Zagreb, Croatia
Neuro Health Centrum s.r.o.
🇨🇿Brno-Lisen, Czechia
AGE Centrum
🇨🇿Olomouc, Czechia
Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin
🇫🇷Bordeaux, France
Hospices Civils de Lyon-Hopital Pierre Wertheimer
🇫🇷Bron, France
Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
🇫🇷Dijon, France
Assistance Publique Hopitaux de Marseille-Hopital de La Timone-1
🇫🇷Marseille, France
Centre Hospitalier Universitaire de Nice-Institut Claude Pompidou
🇫🇷Nice, France
Aphp-Hopital Lariboisiere-1
🇫🇷Paris, France
Aphp-Hopital La Pitie Salpetriere-3
🇫🇷Paris, France
Centre Hospitalier Universitaire Reims-Hopital Maison Blanche
🇫🇷Reims cedex, France
Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-2
🇫🇷Saint Herblain, France
Les Hopitaux Universitaires de Strasbourg-Hopital de La Robertsau
🇫🇷Strasbourg, France
Centre Hospitalier Universitaire de Toulouse-Hopital La Grave
🇫🇷Toulouse, France
Hospices Civils de Lyon-Hopital Des Charpennes
🇫🇷Villeurbanne, France
Universitätsklinikum Köln - Klinik und Poliklinik für Psychiatrie und Psychotherapie
🇩🇪Köln, Germany
Universitätsklinikum Münster, Neurologie
🇩🇪Münster, Germany
Henry Dunant Hospital Center,2nd Neurological Department
🇬🇷Athens, Greece
Aiginitio Hospital, 1st Neurology Clinic
🇬🇷Athens, Greece
"Hygeia" General Hospital of Athens, Memory clinic
🇬🇷Athens, Greece
Naval Hospital of Athens
🇬🇷Athens, Greece
University General Hospital of Athens "Attiko"
🇬🇷Chaidari, Athens, Greece
AHEPA General University Hospital
🇬🇷Thessaloniki, Greece
EUROMEDICA General Clinic of Thessaloniki,Neurology Dpt
🇬🇷Thessaloniki, Greece
Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft.
🇭🇺Budapest, Hungary
Semmelweis Egyetem ÁOK
🇭🇺Budapest, Hungary
DE Kenézy Gyula Campus, Pszichiátriai és Pszichoterápiai Klinika
🇭🇺Debrecen, Hungary
DE Gyógyszerfejlesztési Koordinációs Központ Pszichiátria
🇭🇺Debrecen, Hungary
Petz Aladar Megyei Korhaz
🇭🇺Gyor, Hungary
Petz Aladar Megyei Oktato Korhaz
🇭🇺Gyor, Hungary
Bugát Pál Kórház
🇭🇺Gyöngyös, Hungary
Somogy Megyei Kaposi Mór Oktató Kórház
🇭🇺Kaposvár, Hungary
Psychotech Kft.
🇭🇺Pécs, Hungary
Belvárosi Egészségház Kft.
🇭🇺Zalaegerszeg, Hungary
St Vincent's University Hospital
🇮🇪Dublin, Ireland
Mercer's Institute for Successful Aging
🇮🇪Dublin, Ireland
Tallaght University Hospital
🇮🇪Dublin, Ireland
The Stroke and Cognition Institute Rambam Medical Center
🇮🇱Haifa, Israel
Cognitive Neurology Clinic, Rabin Campus, Beilinson Hospital
🇮🇱Petach Tikva, Israel
Cognitive Neurology Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Chaim Sheba Medical Center, Heart Screening Clinic, 1st floor, Room 317
🇮🇱Tel Hashomer, Ramat Gan, Israel
AOU Ospedali Riuniti S.O.D
🇮🇹Ancona, Italy
Azienda Ospedaliera Spedali Civili di Brescia
🇮🇹Brescia, Italy
Università degli studi Gabriele D'Annunzio Chieti-Pescara
🇮🇹Chieti, Italy
AOU Careggi Firenze
🇮🇹Firenze, Italy
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
IRCCS Ospedale San Raffaele Milano
🇮🇹Milano, Italy
ASST Monza e Brianza Ospedale San Gerardo
🇮🇹Monza, Italy
Ospedale Santa Maria della Misericordia
🇮🇹Perugia, Italy
Pol. Uni. Campus Biomedico UOC Neurologia
🇮🇹Roma, Italy
Policlinico Tor Vergata
🇮🇹Roma, Italy
Policlinico Universitario A.Gemelli Servizio Neuropsicologia
🇮🇹Roma, Italy
Fondazione Santa Lucia IRCCS
🇮🇹Roma, Italy
AOU Città della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Iwaki Clinic_Psychosomatic medicine
🇯🇵Anan, Tokushima, Japan
Memory Clinic Ochanomizu
🇯🇵Bunkyo-ku, Tokyo, Japan
Tokyo Medical And Dental University Hospital
🇯🇵Bunkyo-ku,Tokyo, Japan
Kashiwado Hospital
🇯🇵Chib-shi, Chiba, Japan
Enomoto Internal Medicine Clinic
🇯🇵Chofu-shi,Tokyo, Japan
Shinozuka Hospital
🇯🇵Fujioka-Shi, Gunma, Japan
Hikaru-kai Medical Corporation Hiroshima Neurology Clinic
🇯🇵Hiroshima-shi, Hiroshima, Japan
Hiroshima Neurology Clinic
🇯🇵Hiroshima-shi, Hiroshima, Japan
Nagamitsu Clinic
🇯🇵Hofu-shi, Yamaguchi, Japan
Ina Central Hospital
🇯🇵Ina-shi, Nagano, Japan
Kawasaki Saiwai Clinic_Internal Medicine
🇯🇵Kanagawa, Japan
Teikyo University Hospital, Mizonokuchi_Kawasaki-shi, Kanagawa
🇯🇵Kawasaki-shi, Kanagawa, Japan
Kobe University Hospital_Kobe-shi, Hyogo
🇯🇵Kobe-shi, Hyogo, Japan
National Center of Neurology and Psychiatry
🇯🇵Kodaira-shi, Tokyo, Japan
Southern Tohoku Medical Clinic
🇯🇵Koriyama-shi, Fukushima, Japan
Katayama Medical Clinic
🇯🇵Kurashiki-shi, Okayama, Japan
Nozomi Memory Clinic
🇯🇵Mitaka-shi,Tokyo, Japan
Kikukawa clinic
🇯🇵Nerima-ku, Tokyo, Japan
General Rehabilitation Center · Midori Hospital
🇯🇵Niigata-shi, Niigata, Japan
National Center for Geriatrics and Gerontology
🇯🇵Obu-shi, Aichi, Japan
Jichiidai Station Brain Clinic
🇯🇵Shimotsuke-shi, Tochigi, Japan
Keio University Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Kagawa Prefectural Central Hospital_Takamatsu-shi, Kagawa
🇯🇵Takamatsu-shi, Kagawa, Japan
Takatsuki General Hospital
🇯🇵Takatsuki-Shi, Osaka, Japan
Saino Clinic
🇯🇵Tokorozawa-shi,Saitama, Japan
Itsuki Hospital
🇯🇵Tokushima-shi, Tokushima, Japan
Alzclinic Tokyo
🇯🇵Tokyo, Japan
Tokyo Center Clinic
🇯🇵Tokyo, Japan
Juntendo Tokyo Koto Geriatric Medical Center
🇯🇵Tokyo, Japan
Kurumi CLINIC
🇯🇵Tokyo, Japan
Tokyo Medical Univ. Hospital
🇯🇵Tokyo, Japan
Memory Clinic Toride
🇯🇵Toride-shi, Ibaraki, Japan
MI Clinic
🇯🇵Toyonaka-shi, Osaka, Japan
Medical Corporation Midorikai Wako Hospital
🇯🇵Wako-shi, Saitama, Japan
Dong-A University Medical Center
🇰🇷Busan, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
🇷🇴Constanta, Romania
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Inha University Hospital
🇰🇷Incheon, Korea, Republic of
Hanyang University Medical Center
🇰🇷Seoul, Korea, Republic of
Hanyang university seoul hospital
🇰🇷Seoul, Korea, Republic of
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center_Seoul
🇰🇷Seoul, Korea, Republic of
Ewha Womans University Seoul Hospital
🇰🇷Seoul, Korea, Republic of
Amphia Ziekenhuis
🇳🇱Breda, Netherlands
Brain Research Center
🇳🇱Den Bosch, Netherlands
Radboudumc
🇳🇱Nijmegen, Netherlands
Linden sp. z o.o. sp. k.
🇵🇱Kraków, Małopolskie, Poland
Centrum Medyczne Neuromed
🇵🇱Bydgoszcz, Poland
Centrum Zdrowia Psychicznego Biomed
🇵🇱Kielce, Poland
Szpital Uniwersytecki w Krakowie od. Neurologii
🇵🇱Kraków, Poland
Centrum Neurologii Klinicznej
🇵🇱Kraków, Poland
Nzoz Neuromed
🇵🇱Lublin, Poland
INSTYTUT ZDROWIA DR BOCZARSKA-JEDYNAKSp. z o.o. Sp. k.
🇵🇱Oswiecim, Poland
Unidade Local De Saude De Matosinhos E.P.E.
🇵🇹Senhora Da Hora, Matosinhos, Matosinhos, Portugal
Hospital de Braga
🇵🇹Braga, Portugal
Unidade Local de Saúde de Coimbra, E.P.E.
🇵🇹Coimbra, Portugal
Unidade Local de Saude do Alto Ave, E.P.E.
🇵🇹Guimarães, Portugal
Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital Egas Moniz
🇵🇹Lisboa, Portugal
Hospital Beatriz Ângelo
🇵🇹Loures, Portugal
Unidade Local de Saúde de Santo António, E.P.E
🇵🇹Porto, Portugal
Campus Neurologico Senior
🇵🇹Torres Vedras, Portugal
Spitalul Clinic Cai Ferate Constanta
🇷🇴Constanta, Romania
Aria Clinic SRL
🇷🇴Sibiu, Romania
SAHI SR "Sverdlovsk Regional Clinical Psychiatric Hospital"
🇷🇺Ekaterinburg, Russian Federation
Joint Stock Company "Medical technologies"
🇷🇺Ekaterinburg, Russian Federation
FSAEI 1st Moscow Federal Med University na Sechenov
🇷🇺Moscow, Russian Federation
RMAPE
🇷🇺Moscow, Russian Federation
Pirogov Russian National Research Medical University MoH
🇷🇺Moscow, Russian Federation
Ezramed Clinic Llc
🇷🇺Omsk, Russian Federation
Research Center for Treatment and Rehabilitation "Phoenix"
🇷🇺Rostov-on-Don, Russian Federation
Psychiatric hospital of st. Nicholas the wonderworker
🇷🇺Saint Petersburg, Russian Federation
N.-E. State Medical University n.a. Mechnikov
🇷🇺Saint Petersburg, Russian Federation
Center of Clinica Trials "Nebbiolo"
🇷🇺Tomsk, Russian Federation
LLC "Clinic Stolet"
🇷🇺Tomsk, Russian Federation
National medical holdiNational medical holding "Medstandard"
🇷🇺Ufa, Russian Federation
Neurology clinic, University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Special Hospital for Psychiatric Disorders "Kovin"
🇷🇸Kovin, Serbia
University clinical center of Vojvodina, Neurology clinic
🇷🇸Novi Sad, Serbia
I. neurologicka klinika LF UK a UNB
🇸🇰Bratislava, Slovakia
Psychiatricka klinika LF UK a UNB
🇸🇰Bratislava, Slovakia
Neurologicka klinika UPJS LF a UNLP
🇸🇰Kosice, Slovakia
NEURES, neurologicka ambulancia
🇸🇰Krompachy, Slovakia
Crystal Comfort s.r.o.
🇸🇰Vranov nad Toplou, Slovakia
UKC Ljubljana, Department of Neurology
🇸🇮Ljubljana, Slovenia
UKC Maribor - neurology
🇸🇮Maribor, Slovenia
Excellentis Clinical Trial Consultants
🇿🇦George, Eastern Cape, South Africa
IATROS International
🇿🇦Bloemfontein, Free State, South Africa
Dr Stanley Lipschitz Clinic Inc
🇿🇦Johannesburg, Gauteng, South Africa
Denmar Psychiatric Hospital
🇿🇦Pretoria, Gauteng, South Africa
ACF Neurological service
🇿🇦Cape Town, Western Cape, South Africa
Flexivest Fourteen Research Centre
🇿🇦Cape Town, Western Cape, South Africa
Cape Trial Centre
🇿🇦Cape Town, Western Cape, South Africa
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario Doctor Peset
🇪🇸Valencia, Spain
Minnesmottagning specialiserad Malmö
🇸🇪Malmö, Sweden
Karolinska Universitetssjukhuset, Huddinge
🇸🇪Stockholm, Sweden
Klinik für Neurologie Kantonsspital St.Gallen
🇨🇭St. Gallen, Switzerland
Chang Gung Memorial Hospital - Kaoshiung Branch
🇨🇳Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veteran General Hospital
🇨🇳Taipei, Taiwan
Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma
🇹🇷Eskisehir, Turkey
Istanbul University Medical Faculty Neurology Department
🇹🇷Istanbul, Turkey
Izmir Economics University Medical Point Hospital Neurology D
🇹🇷Izmir, Turkey
Ondokuz Mayis University Saglik Uygulama ve Arastirma Merkez
🇹🇷Samsun, Turkey
Medical Center 'Neiron'
🇺🇦Kharkiv, Ukraine
Fritchie Centre
🇬🇧Cheltenham, Gloucestershire, United Kingdom
Royal Cornhill Hospital
🇬🇧Aberdeen, United Kingdom
RICE - The Research Institute for the Care of Older People
🇬🇧Bath, United Kingdom
Ninewells Hospital
🇬🇧Dundee, United Kingdom
Western General Hospital
🇬🇧Edinburgh, United Kingdom
St Pancras Clinical Research
🇬🇧London, United Kingdom
St George's Hospital
🇬🇧London, United Kingdom
Imperial College London - Imperial College Memory Research Centre
🇬🇧London, United Kingdom
Greater Manchester Mental Health NHS Foundation Trust
🇬🇧Manchester, United Kingdom
NeuroClin
🇬🇧Motherwell, United Kingdom
Newcastle University
🇬🇧Newcastle Upon Tyne, United Kingdom
Warneford Hospital
🇬🇧Oxford, United Kingdom
Moorgreen Hospital
🇬🇧Southampton, United Kingdom
Kings Hill Research Centre
🇬🇧Swindon, United Kingdom