Reduction of the Glycemic Index by a Novel Viscous Polysaccharide

Phase 2

Completed

• Conditions: Blood Glucose, Postprandial
• Interventions: Dietary Supplement: PolyGlycopleX (PGX)

• Registration Number: NCT00935350
• Lead Sponsor: Glycemic Index Laboratories, Inc

Brief Summary

Reductions of postprandial glucose levels have been demonstrated previously with the addition of a novel viscous polysaccharide (NVP) to a glucose drink and standard white bread. This study explores whether these reductions are sustained when NVP is added to a range of commonly consumed foods.

Detailed Description

Recently, a commercial novel viscous polysaccharide (NVP)complex has been developed which is marketed in both the USA and Canada under the trade name PGX® (PolyGlycopleX) (InovoBiologic Inc, Calgary, AB, Canada). This complex consists of three viscous non starch polysaccharides which are processed using proprietary technology (EnviroSimplex®) to produce compressed granules which delays the onset of viscosity and increases palatability of the fiber when added to food. Previously, this fibre was shown to lower postprandial glucose levels in a dose responsive manner when mixed with a glucose drink and sprinkled onto a standard white bread demonstrating that the processing did not interfere with the effectiveness of the fiber. From this study the reduction in GI was calculated to be 7 units per gram of NVP when added to a solid food, however it is not known whether this relationship would be maintained when the NVP was added to a range of commonly eaten foods. This study therefore evaluates the effect of the addition or incorporation of NVP into a range of foods on postprandial glycemia and whether the reductions in glycemic index could be predicted using.

Study Timeline

• Study Start: 2006-05
• Primary Completion: 2006-06
• Study Completion: 2006-08
• Study First Submitted: 2009-03-25
• Status Verified: 2009-07
• Study First Submitted QC: 2009-07-08
• Last Update Submitted: 2009-07-08
• Study First Posted: 2009-07-09
• Last Update Posted: 2009-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• healthy individuals
• 18-75 years old
• BMI less than 35 kg/m2

Exclusion Criteria

• Medications influencing gastrointestinal function
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1	PolyGlycopleX (PGX)	Control White bread containing 50g available carbohydrate
2	PolyGlycopleX (PGX)	White bread and milk control
3	PolyGlycopleX (PGX)	Granola control
4	PolyGlycopleX (PGX)	Cornflakes and milk control
5	PolyGlycopleX (PGX)	White rice control
6	PolyGlycopleX (PGX)	Fruit yogurt control
7	PolyGlycopleX (PGX)	Turkey dinner control
8	PolyGlycopleX (PGX)	Granola
9	PolyGlycopleX (PGX)	Cornflakes and milk
10	PolyGlycopleX (PGX)	White Rice
11	PolyGlycopleX (PGX)	Fruit yogurt
12	PolyGlycopleX (PGX)	Turkey dinner
13	PolyGlycopleX (PGX)	White Bread
14	PolyGlycopleX (PGX)	White bread
15	PolyGlycopleX (PGX)	Granola

Primary Outcome Measures

Name	Time	Method
Relative Blood glucose response of food with and without NVP	Acute blood glucose response measured at 0, 15,30,45,60,90 and 120 min

Trial Locations

Locations (1)

Glycemic Index Laboratories, Inc.; 🇨🇦 Toronto, Ontario, Canada