Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

Not Applicable

Completed

• Conditions: Postprandial Hyperglycemia
• Interventions: Dietary Supplement: Control; Dietary Supplement: Test 3; Dietary Supplement: Test 1; Dietary Supplement: Test 2

• Registration Number: NCT02654301
• Lead Sponsor: Yonsei University

Brief Summary

The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

Detailed Description

In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Study Timeline

• Study Start: 2014-06
• Primary Completion: 2014-12
• Study Completion: 2015-02
• Status Verified: 2015-08
• Study First Submitted: 2015-08-26
• Study First Submitted QC: 2016-01-12
• Last Update Submitted: 2016-01-12
• Study First Posted: 2016-01-13
• Last Update Posted: 2016-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)

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Exclusion Criteria

1. history of taking an insulin-injection or oral hypoglycemic agents
2. evidence of alcohol abuse or alcoholism
3. pregnancy or breast feeding
4. chronic gastrointestinal disorder
5. seriously abnormal liver or renal function
6. an occupation at risk of death when hypoglycemia occurs

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control group	Control	sucrose drink (Control, sucrose 50g + deionized water 100g)
2.5 g xylose group	Test 3	2.5 g xylose (Test 3, sucrose : xylose = 20:1)
5 g xylose group	Test 1	5 g xylose (Test 1, sucrose : xylose = 10:1),
3.33 g xylose group	Test 2	3.33 g xylose (Test 2, sucrose : xylose = 15:1)

Primary Outcome Measures

Name	Time	Method
Change of serum glucose levels	a week interval

Secondary Outcome Measures

Name	Time	Method
Change of serum insulin levels	a week interval
Change of serum C-peptide levels	a week interval