Cognitive Enhancement Through Computerized Training

Not Applicable

Terminated

Interventions: Behavioral: Inhibitory Control Training
Behavioral: Working Memory Training
Behavioral: Bias Modification Training

Brief Summary: Alcohol use disorder is characterized by widespread neurocognitive impairments, however despite substantial advances in the intervention and treatment of alcohol use disorders, exceptionally few studies have been directed to improving these deficits. This project leverages computerized cognitive training, applied as an adjunct to inpatient treatment, to enhance neurocognitive recovery. This project informs public health and future intervention efforts by interrogating factors critical to intervention efficacy and clarifying relationships between neurocognitive recovery and treatment outcomes, including post-discharge alcohol consumption.

Detailed Description: Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. This project is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD.

The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current project will interrogate the degree to which cognitive training interventions can "transfer" cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post-discharge adaptation will be examined. Thus, the current work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Medical histories confounding interpretation regarding change in neuropsychological functioning (e.g., stroke)
Meet DSM-5 criteria for current/unremitted psychotic, panic, or bipolar disorders

Arm && Interventions

Group	Intervention	Description
Inhibitory Control Training (IC)	Inhibitory Control Training	Participants complete training in an inhibitory control task designed to utilize individually-adapted difficulty levels.
Working Memory Training (WM)	Working Memory Training	Participants complete training in a working memory task designed to utilize individually-adapted difficulty levels.
Bias Modification Training (BM)	Bias Modification Training	Participants complete training in an active comparator task designed to weaken approach responses to alcohol-associated cues.

Primary Outcome Measures

Name	Time	Method
Working Memory	Baseline and up to 3 weeks	Performance on neuropsychological measures indexing working memory capacity. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).
Inhibitory Control	Baseline and up to 3 weeks	Performance on neuropsychological measures indexing inhibitory control capacity. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).
General Executive Function	Baseline and up to 3 weeks	Performance on neuropsychological measures indexing general executive functioning. Score range: 0-100 (scores \<40 are poor \[0-16th percentile\]; scores \>60 are good \[84th-100th percentile\]).

Secondary Outcome Measures

Name	Time	Method