To explore the mechanism of promoting blood circulation and detoxifying Traditional Chinese medicine Zhizi Chuanxiong capsule on atherosclerosis from DNA methylation and downstream MAPK signaling pathway

Xiyuan Hospital,China Academy of Chinese Medical Sciences0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

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•? Age from 30 to 75, no gender limitation;
•? Patients with stable angina or unstable angina with coronary angiography and/or coronary CT confirmed at least one coronary artery stenosis =50% or with a clear history of myocardial infarction. Coronary angiography results were confirmed by 2 physicians with professional titles above deputy director;
•? Patients with heat-toxin and blood-stasis syndrome and cold-coagulation and blood-stasis syndrome in TCM syndrome type diagnostic criteria.
•? Sign informed consent.

•Those who possess any of the following are excluded:
•? Congenital heart disease, cardiomyopathy, coronary spasm, severe cardiopulmonary insufficiency (heart function above grade III, severe lung insufficiency);
•? patients with acute cerebrovascular disease;
•? Patients with hypertension and poor blood pressure control (systolic blood pressure = 180mmHg, diastolic blood pressure = 110mmHg);
•? Complicated with chronic inflammatory diseases, severe infection, diabetes and poor blood glucose control, malignant arrhythmia, malignant tumor and multiple organ failure;
•(5) with serious primary diseases such as liver, kidney and hematopoietic system, mental disorders can not express their will correctly and communication disorders;
•? Patients who are participating in clinical trials of other drugs;
•? Pregnant or lactating women;
•? Alcoholism and drug abuse and addiction.

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