MedPath

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice

Active, not recruiting
Conditions
Urothelial Carcinoma
Non-Small Cell Lung Cancer
Small Cell Lung Cancer
Hepatocellular Carcinoma
Interventions
Registration Number
NCT03782207
Lead Sponsor
Hoffmann-La Roche
Brief Summary

This is a non-interventional, multi-country, multi-centre, multiple cohort prospective study, with retrospective collection of prior medical/treatment history data from medical records, designed to assess the real-world outcomes and safety of atezolizumab for indications in the existing label in the real world setting of routine clinical practice.

Detailed Description

The study will be split into separate cohorts based on the approved indications for atezolizumab treatment, excluding cisplatin ineligible participants receiving atezolizumab as first line of therapy (LOT1) for locally advanced/metastatic urothelial cancer (locally advanced/metastatic UC). The study may be amended for inclusion of new cohorts as these are approved in the participating countries. Participants will be included into each cohort based on their indication for receiving atezolizumab.

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
2756
Inclusion Criteria
  • Patient must have one of the following confirmed diagnoses for which atezolizumab is locally approved in the SmPC: (1) As monotherapy for the treatment of adult patients with locally advanced/metastatic UC after prior platinum-containing chemotherapy (Cohort 1 LOT2+mUC) or (2) As monotherapy for the treatment of adult patients with locally advanced/metastatic NSCLC after prior chemotherapy. Patients with EGFR activating mutations or ALK-positive tumour mutations should also have received targeted therapy before receiving atezolizumab (Cohort 2 LOT2+NSCLC) or (3) In combination with bevacizumab, paclitaxel and carboplatin for the first line treatment of adult patients with metastatic non-squamous NSCLC. Patients with EGFR activating mutations or ALK- positive tumour mutations should also have received targeted therapy (Cohort 3 LOT1 NSCLC) or (4) In combination with carboplatin and etoposide, is indicated for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) (Cohort 4 LOT1 ES-SCLC) or (5) As a monotherapy, for the treatment of metastatic NSCLC with high PD-L1 expression, previously untreated (Cohort 5 LOT1 NSCLC) or (6) In combination with bevacizumab for unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy (Cohort 6 LOT1 HCC) .
  • Patient is administered atezolizumab therapy for the first time.
  • Decision to administer atezolizumab must be made and documented prior to inclusion into the study and must follow local clinical practice.
Exclusion Criteria
  • Patients not receiving treatment for a disease with atezolizumab according to standard of care and in line with the current summary of product characteristics (SPC) or local labelling. Cisplatin ineligible patients receiving atezolizumab LOT1 for the treatment of locally advanced/metastatic UC patients will be excluded
  • Concomitant anti-cancer therapy at the time of starting atezolizumab on the index date not part of locally approved combination therapy with atezolizumab.
  • Treatment with atezolizumab as part of a clinical trial or for compassionate use as part of a pre-approval or compassionate use program.
  • Patients not receiving atezolizumab, but a biosimilar or non-original biologic.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Cohort 5 (NSCLC LOT1)AtezolizumabParticipants diagnosed with metastatic Non-Small Cell Lung cancer with high PD-L1 expression, previously untreated.
Cohort 4 (ES-SCLC LOT1)AtezolizumabParticipants diagnosed with extensive stage (ES) small cell lung cancer (SCLC) not previously treated. Enrollment is closed.
Cohort 1 (UC LOT2+later lines[LOT2+] & platinum eligible LOT1)AtezolizumabParticipants diagnosed with locally advanced or metastatic Urothelial Cancer previously treated with platinum-containing chemotherapy. Enrollment is closed.
Cohort 2 (NSCLC LOT2 plus later lines [LOT2+])AtezolizumabParticipants diagnosed with Locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) after prior chemotherapy. Participants with epidermal growth factor receptor (EGFR) activating mutations or anaplastic lymphoma kinase (ALK)-positive tumor mutations should also have received targeted therapy. Enrollment closed.
Cohort 3 (NSCLC LOT1 plus EGFR+/ALK+ LOT2+)AtezolizumabEMA: Participants diagnosed with locally advanced/metastatic non-squamous NSCLC not previously treated. Participants with EGFR-activating mutations or ALK-positive tumor mutations should have received at least one line of targeted therapy. FDA: for the treatment of adult participants with metastatic NSCLC who have disease progression during or following platinum-containing chemotherapy. Participants with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for NSCLC harboring these aberrations prior to receiving TECENTRIQ. Enrollment is closed.
Cohort 6 (HCC LOT1)AtezolizumabParticipants diagnosed with unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy.
Primary Outcome Measures
NameTimeMethod
OS at 2 YearsAfter index date up to 2 years

Percentage of participants alive 2 years after initiation of atezolizumab treatment.

Overall Survival (OS)Index date up to approximately 6 years

Time from index date until date of death from any cause. Index date is the date of administration of the first ever dose of atezolizumab for each patient.

Secondary Outcome Measures
NameTimeMethod
Duration of Response (DoR)Index date up to approximately 6 years

Time from first documentation of CR or PR (whichever occurs first) after index until death or PD.

Time to Loss of Clinical Benefit (TTLCB)Index date up to approximately 6 years

Time from the index date to loss of clinical benefit as assessed by the treating physician.

Progression Free Survival (PFS)Index date up to approximately 6 years

Time from index date to death or disease progression (PD).

Objective Response Rate (ORR)After index date up to approximately 6 years

Percentage of participants who have a best overall response (BOR) of Complete Response (CR) or Partial Response (PR). BOR for each participant is the best response achieved after the index date prior to initiation of any subsequent treatment.

Time to ResponseIndex date up to approximately 6 years

Time from index date to first objective tumor response, CR or PR.

EuroQol 5-Dimension 5-Level (EQ-5D-5L) Questionnaire ScoreIndex date or after ICF signature, & approx. at 6, 12, and 24 weeks of treatment; then at approx. 3 months, 6 months, 12 months, & every 12 months thereafter until end of study (study planned duration up to approximately 6 years)

EQ-5D-5L during and after atezolizumab treatment will be used to assess HRQoL. Scale is from 1-5 (no problems, slight problems, moderate problems, severe problems and extreme problems).

Total Number of Infusions of AtezolizuambTreatment period until discontinuation (up to approximately 6 years)
Duration of Treatment With AtezolizumabIndex date until date of treatment discontinuation (up to approximately 6 years)
Time to initiation of the first subsequent cancer-related therapyUp to approximately 6 years
Number of Lines of Prior and Subsequent Cancer-Related TherapiesUp to approximately 6 years
Disease Control Rate (DCR)From 12 weeks after index date up to approximately 6 years

Percentage of participants who have achieved CR, PR and stable disease at least 12 weeks after the index date.

Duration of DCRAfter index date up to approximately 6 years

Time from first documentation of CR, PR or stable disease (whichever occurs first) after index until death or PD.

Number of Participants at Each Level of Karnofsky or ECOG Performance StatusAt index date (Index date is the date of administration of the first ever dose of atezolizumab for each patient.
Number of Paricipants with Disease Stage TNM and IUCCAt index date (Index date is the date of administration of the first ever dose of atezolizumab for each patient.)
Percentage of Participants with Adverse EventsUp to approximately 6 years

Trial Locations

Locations (256)

Multiprofile Hospital for Active Treatment Uni Hospital

🇧🇬

Panagyurishte, Bulgaria

Umhat Dr Georgi Stranski

🇧🇬

Pleven, Bulgaria

University Hospital Palmed

🇧🇬

Plovdiv, Bulgaria

Complex Oncological Center - Plovdiv, EOOD

🇧🇬

Plovdiv, Bulgaria

DDODIU-Plovdiv, EOOD

🇧🇬

Plovdiv, Bulgaria

Complex Oncological Center-Ruse EOOD

🇧🇬

Ruse, Bulgaria

Tokuda Hospital

🇧🇬

Sofia, Bulgaria

MHAT SofiaMed

🇧🇬

Sofia, Bulgaria

Fundacion Clinica Valle del Lili

🇨🇴

Cali, Colombia

Klinicki Bolnicki Centar Split

🇭🇷

Split, Croatia

International Medical Center

🇪🇬

Cairo, Egypt

North Estonia Medical Centre Foundation

🇪🇪

Tallinn, Estonia

Tartu Uni Hospital

🇪🇪

Tartu, Estonia

Clinique Du Docteur Calabet

🇫🇷

Agen, France

Ch Du Pays D Aix

🇫🇷

Aix En Provence, France

Clinique de l'Europe

🇫🇷

Amiens, France

Centre Hospitalier Uni Ire

🇫🇷

Angers, France

Hopital Prive D Antony

🇫🇷

Antony, France

Hopital Jean Minjoz

🇫🇷

Besancon, France

Ch De Beziers

🇫🇷

Beziers, France

Clinique Tivoli

🇫🇷

Bordeaux, France

Polyclinique Bordeaux Nord Aquitaine

🇫🇷

Bordeaux, France

Hopital Cote De Nacre

🇫🇷

Caen, France

Ch De Chambery

🇫🇷

Chambery, France

Oncologie 37

🇫🇷

Chambray Les Tours, France

Hopital Gabriel Montpied

🇫🇷

Clermont-ferrand, France

Ch De Compiegne

🇫🇷

Compiegne, France

Ch Laennec

🇫🇷

Creil, France

Centre Georges Francois Leclerc

🇫🇷

Dijon, France

Hopital Simone Veil Eaubonne

🇫🇷

Eaubonne, France

Chi Alpes Du Sud Site De Gap

🇫🇷

GAP, France

Hopital Nord Ouest

🇫🇷

Gleize, France

Ch Saint Louis

🇫🇷

La Rochelle, France

Hopital La Source

🇫🇷

La Source, France

Hopital Louis Pasteur

🇫🇷

Le Coudray, France

Centre Hospitalier Du Mans

🇫🇷

Le Mans, France

Hôpital Privé La Louviere

🇫🇷

Lille, France

Hopital Dupuytren

🇫🇷

Limoges, France

Ch Bretagne Sud Site Scorff

🇫🇷

Lorient, France

Hopital Privé Jean Mermoz

🇫🇷

Lyon, France

Clinique Clementville

🇫🇷

Montpellier, France

Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque

🇫🇷

Montpellier, France

Hopital Emile Muller

🇫🇷

Mulhouse, France

Arkhangelsk Regional Clinical Oncology Dispensary

🇷🇺

Arkhangelsk, Arhangelsk, Russian Federation

Semmelweis Egyetem, AOK, Pulmonologiai Klinika

🇭🇺

Budapest, Hungary

Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika

🇭🇺

Debrecen, Hungary

HCG Cancer Center

🇮🇳

Ahmedabad, Gujarat, India

Sunshine Global Hospital (A unit of Baroda Medicare Pvt Ltd)

🇮🇳

Surat CITY, Gujarat, India

Manipal Hospital

🇮🇳

Bangalore, Karnataka, India

Aster Medcity

🇮🇳

Kochi, Kerala, India

MVR Cancer Centre and Research Institute

🇮🇳

Kozhikode, Kerala, India

MOC Cancer Care & Research Centre

🇮🇳

Mumbai, Maharashtra, India

AIG Hospitals

🇮🇳

Gachibowli, Telangana, India

Ospedale San Salvatore, UOC Oncologia

🇮🇹

L?Aquila, Abruzzo, Italy

Kuwait Cancer control center

🇰🇼

Shuwakh Industrial, Kuwait

Middle East Institute of Health Hospital

🇱🇧

Bsalim, Mount Lebanon-Metn, Lebanon

Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution

🇱🇹

Kaunas, Lithuania

Medica sur Hospital

🇲🇽

Mexico City, Mexico CITY (federal District), Mexico

Clinica Opcion Oncologia S.A. de C.V.

🇲🇽

Monterrey, Nuevo LEON, Mexico

Oncare

🇲🇽

San Pedro Garza García, Nuevo LEON, Mexico

Onze Lieve Vrouwe Gasthuis, locatie Oost

🇳🇱

Amsterdam, Netherlands

Catharina ziekenhuis

🇳🇱

Eindhoven, Netherlands

Medisch Centrum Leeuwarden

🇳🇱

Leeuwarden, Netherlands

Zaans Medisch Centrum

🇳🇱

Zaandam, Netherlands

Sultan Qaboos Comprehensive Cancer Care & Research Center

🇴🇲

Muscat, Oman

Wojewódzki Szpital Specjalistyczny im. M. Kopernika w ?odzi

🇵🇱

?ód?, Poland

Instytut Gruzlicy i Chorob P?uc

🇵🇱

Warszawa, Poland

Institutul Clinic Fundeni Bucuresti

🇷🇴

Bucharest, Romania

Institutul Regional de Gastroenterologie si Hepatologie Prof. Dr. Octavian Fodor

🇷🇴

Cluj-Napoca, Romania

AZ Delta (Campus Rumbeke)

🇧🇪

Roeselare, Belgium

Complex Oncology Center Burgas

🇧🇬

Burgas, Bulgaria

Centrum Pulmonologii i Torakochirurgii

🇵🇱

Bystra, Poland

Wojewodzki Szpital Zespolony

🇵🇱

Elblag, Poland

Regionalny Szpital Specjalistyczny im. W. Bieganskiego

🇵🇱

Grudzi?dz, Poland

The York Hospital

🇬🇧

York, United Kingdom

AZ KLINA

🇧🇪

Brasschaat, Belgium

AZ Damiaan

🇧🇪

Oostende, Belgium

Hospital Universitario Austral

🇦🇷

Buenos Aires, Argentina

Hospital Italiano de Buenos Aires

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

Klinikum Klagenfurt

🇦🇹

Klagenfurt, Austria

Landesklinikum Krems

🇦🇹

Krems, Austria

Klinikum Wels-Grieskirchen

🇦🇹

Wels, Austria

Hopital Caremeau

🇫🇷

Nimes, France

Polyclinique Kenval

🇫🇷

Nimes, France

Institut Curie

🇫🇷

Paris, France

Hopital Cochin

🇫🇷

Paris, France

Hopital Europeen Georges Pompidou

🇫🇷

Paris, France

Centre Hospitalier

🇫🇷

PAU, France

Centre Catalan D' Oncologie

🇫🇷

Perpignan, France

Ch Annecy - Genevois

🇫🇷

Pringy, France

Hopital De La Maison Blanche

🇫🇷

Reims, France

Clinique Mutualiste L Estuaire

🇫🇷

Saint Nazaire, France

Hopital Nord

🇫🇷

Saint Priest En Jarez, France

Hopital Robert Pax

🇫🇷

Sarreguemines, France

Ch De Saint Quentin

🇫🇷

St Quentin, France

Hopital Sainte Musse

🇫🇷

Toulon, France

Hopital Larrey

🇫🇷

Toulouse, France

Centre Hospitalier de Valence

🇫🇷

Valence, France

Ch Bretagne Atlantique

🇫🇷

Vannes, France

Hopital Robert Schuman

🇫🇷

Vantoux, France

University of Pecs

🇭🇺

Pecs, Hungary

Református Pulmonológiai Centrum

🇭🇺

Törökbálint, Hungary

Grande Ospedale Metropolitano

🇮🇹

Reggio Calabria, Calabria, Italy

Az. Osp. Monaldi

🇮🇹

Napoli, Campania, Italy

Istituto Nazionale Tumori Fondazione G. Pascale

🇮🇹

Napoli, Campania, Italy

A.O. Universitaria Policlinico Di Modena

🇮🇹

Modena, Emilia-Romagna, Italy

Azienda Ospedaliera San Camillo Forlanini

🇮🇹

Roma, Lazio, Italy

Ospedale S.S. Trinità Nuovo

🇮🇹

Sora, Lazio, Italy

Centrum Onkologii im. Prof. Franciszka ?ukaszczyka

🇵🇱

Bydgoszcz, Poland

IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST)

🇮🇹

Genova, Liguria, Italy

Ospedale Maggiore Policlinico

🇮🇹

Milano, Lombardia, Italy

Asst Santi Paolo E Carlo

🇮🇹

Milano, Lombardia, Italy

Asst Grande Ospedale Metropolitano Niguarda

🇮🇹

Milano, Lombardia, Italy

Ospedale Di Circolo E Fondazione Macchi

🇮🇹

Varese, Lombardia, Italy

Ospedale Di Macerata

🇮🇹

Macerata, Marche, Italy

Ospedale Civile SS. Antonio E Biagio DI Alessandria

🇮🇹

Alessandria, Piemonte, Italy

Ospedale Oncologico A.Businco

🇮🇹

Cagliari, Sardegna, Italy

Azienda Ospedaliero Universitaria Di Sassari

🇮🇹

Sassari, Sardegna, Italy

Az Ospedaliera Nuovo Garibaldi Quartiere Nesima

🇮🇹

Catania, Sicilia, Italy

Az. Osp. Uni. Ria Policlinico G. Martino

🇮🇹

Messina, Sicilia, Italy

Azienda Ospedaliero Universitaria Careggi

🇮🇹

Firenze, Toscana, Italy

Azienda Ospedaliero-Universitaria Careggi

🇮🇹

Firenze, Toscana, Italy

Ospedale Nuovo Della Versilia

🇮🇹

Lido Di Camaiore, Toscana, Italy

A.O.U. Integrata Verona - Policlinico G.B. Rossi

🇮🇹

Verona, Veneto, Italy

Saint George Hospital

🇱🇧

Beirut, Lebanon

National Cancer Institute

🇱🇹

Vilnius, Lithuania

Royal Hospital

🇴🇲

Muscat, Oman

Azienda ULSS 8 Berica

🇮🇹

Vicenza, Veneto, Italy

Shaukat Khanum Memorial Cancer Hospital

🇵🇰

Lahore, Punjab (province), Pakistan

Aga Khan University

🇵🇰

Karachi, Sindh (province), Pakistan

WZZOZ Centrum Leczenia Chorob Pluc i Rehabilitacji

🇵🇱

?ód?, Poland

Beskidzkie Centrum Onkologii - Szpital Miejski im. Jana Pawla II

🇵🇱

Bielsko-Bia?a, Poland

Uniwersytecki Szpital Kliniczny nr 4 w Lublinie

🇵🇱

Lublin, Poland

Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

🇵🇱

Olsztyn, Poland

Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy

🇵🇱

Otwock, Poland

Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu

🇵🇱

Pozna?, Poland

Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego

🇵🇱

Warszawa, Poland

Dolno?L?Skie Centrum Onkologii, Pulmonologii I Hematologii

🇵🇱

Wroc?aw, Poland

Hospital Geral

🇵🇹

Coimbra, Portugal

Centro Clinico Champalimaud

🇵🇹

Lisboa, Portugal

Hospital Pulido Valente

🇵🇹

Lisboa, Portugal

Hospital Pedro Hispano

🇵🇹

Matosinhos, Portugal

Centro Hospitalar do Porto ? Hospital de Santo António

🇵🇹

Porto, Portugal

Hospital CUF Porto

🇵🇹

Porto, Portugal

CHVNG/E_Unidade 1

🇵🇹

Vila Nova De Gaia, Portugal

Altai Regional Oncological Center

🇷🇺

Barnaul, Altaj, Russian Federation

Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky

🇷🇺

Krasnoyarsk, Krasnodar, Russian Federation

Tan Tock Seng Hospital

🇸🇬

Singapore, Singapore

Institute of Oncology Ljubljana

🇸🇮

Ljubljana, Slovenia

University Medical Center Ljubljana

🇸🇮

Ljubljana, Slovenia

Univerzitetni klini?ni center Maribor

🇸🇮

Maribor, Slovenia

Complejo Hospitalario Torrecardenas

🇪🇸

Almería, Almeria, Spain

Hospital General de Mataro

🇪🇸

Mataro, Barcelona, Spain

Corporacio Sanitaria Parc Tauli

🇪🇸

Sabadell, Barcelona, Spain

Hospital Universitario Son Espases

🇪🇸

Palma De Mallorca, Islas Baleares, Spain

Complejo Hospitalario Universitario de Santiago (CHUS)

🇪🇸

Santiago de Compostela, LA Coruna, Spain

Hospital Infanta Sofia

🇪🇸

San Sebastian de Los Reyes, Madrid, Spain

Clinica Universitaria de Navarra

🇪🇸

Pamplona, Navarra, Spain

Complejo Hospitalario de Navarra

🇪🇸

Pamplona, Navarra, Spain

Hospital Universitario de Canarias

🇪🇸

La Laguna, Tenerife, Spain

Nottingham City Hospital

🇬🇧

Nottingham, United Kingdom

Complejo Hospitalario Nuestra Señora de la Candelaria

🇪🇸

Santa Cruz de Tenerife, Tenerife, Spain

Hospital Universitario Infanta Cristina

🇪🇸

Badajoz, Spain

Hospital Universitari Dexeus - Grupo Quironsalud

🇪🇸

Barcelona, Spain

Hospital de la Santa Creu i Sant Pau

🇪🇸

Barcelona, Spain

Complejo Asistencial Universitario De Burgos

🇪🇸

Burgos, Spain

Hospital San Pedro De Alcantara

🇪🇸

Caceres, Spain

Hospital Clinico de Granada

🇪🇸

Granada, Spain

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico

🇪🇸

Jaen, Spain

Complejo Asistencial Universitario de Leon

🇪🇸

Leon, Spain

Hospital Lucus Augusti

🇪🇸

Lugo, Spain

Hospital Universitario La Paz

🇪🇸

Madrid, Spain

Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal

🇪🇸

Madrid, Spain

Hospital Universitario Puerta de Hierro

🇪🇸

Madrid, Spain

Hospital Quiron de Madrid

🇪🇸

Madrid, Spain

Complejo Hospitalario de Orense

🇪🇸

Orense, Spain

Hospital General de Segovia

🇪🇸

Segovia, Spain

Hospital Univ. Nuestra Señora de Valme

🇪🇸

Sevilla, Spain

Hospital Clinico Universitario de Valladolid

🇪🇸

Valladolid, Spain

Hospital Universitario Miguel Servet

🇪🇸

Zaragoza, Spain

Barnet Hospital

🇬🇧

Barnet, United Kingdom

Royal United Hospital

🇬🇧

Bath, United Kingdom

Heartlands Hospital

🇬🇧

Birmingham, United Kingdom

Castle Hill Hospital

🇬🇧

Cottingham, United Kingdom

Huddersfield Royal Infirmary

🇬🇧

Huddersfield, United Kingdom

Airedale General Hospital

🇬🇧

Keighley, United Kingdom

St James Hospital

🇬🇧

Leeds, United Kingdom

Royal Free Hospital

🇬🇧

London, United Kingdom

St George's Hospital

🇬🇧

London, United Kingdom

Hammersmith Hospital

🇬🇧

London, United Kingdom

Maidstone Hospital

🇬🇧

Maidstone, United Kingdom

Torbay Hospital

🇬🇧

Torquay, United Kingdom

Consultorio Privado Korbenfeld

🇦🇷

Caba, Argentina

Lucen S.A.

🇦🇷

Ciudad Autónoma de Buenos Aires, Argentina

Sanatorio Allende

🇦🇷

Cordoba, Argentina

Sanatorio de la Mujer

🇦🇷

Rosario, Argentina

Fundacion Koriza

🇦🇷

Santa Rosa, Argentina

Salzkammergut-Klinikum Voecklabruck

🇦🇹

Vöcklabruck, Austria

AZ St Maarten Campus Leopoldstr

🇧🇪

Mechelen, Belgium

CHU UCL Mont-Godinne

🇧🇪

Mont-godinne, Belgium

Sint Trudo Ziekenhuis

🇧🇪

Sint-Truiden, Belgium

Beneficencia Portuguesa de Sao Paulo

🇧🇷

Sao Paulo, São Paulo, Brazil

Complex Oncology Center - Plovdiv First Internal Chemotherapy Department

🇧🇬

Plovdiv, Bulgaria

UMHAT "Sv. Ivan Rilski", EAD

🇧🇬

Sofia, Bulgaria

MBAL Serdika EOOD

🇧🇬

Sofia, Bulgaria

Specialized Hospital for Active Cancer Treatment, Dr. Mark Antonov Markov - Varna Ltd

🇧🇬

Varna, Bulgaria

Centro de Estudios Clínicos SAGA

🇨🇱

Santiago, Chile

Angiografia del Occidente

🇨🇴

Cali, Colombia

Hospital Pablo Tobon Uribe

🇨🇴

Medellin, Colombia

Clinica ASTORGA

🇨🇴

Medellin, Colombia

Clinical Hospital Centre Osijek

🇭🇷

Osijek, Croatia

Clinical Hospital Center Sestre Milosrdnice

🇭🇷

Zagreb, Croatia

Clinical Hospital Centre Zagreb

🇭🇷

Zagreb, Croatia

SUN Oncology center- Alexandria

🇪🇬

Alexandria, Egypt

Yasser Abdel Kader Private Clinic

🇪🇬

Cairo, Egypt

Air Force Specialized Hospital

🇪🇬

Cairo, Egypt

Barsoum Oncology Center

🇪🇬

Cairo, Egypt

Cairo Oncology Center

🇪🇬

Cairo, Egypt

CHG Henri Dufaut médecine interne-onco-hematologie

🇫🇷

Avignon, France

CH de Beauvais

🇫🇷

Beauvais, France

Hopital Europeen

🇫🇷

Marseille, France

Service de pneumologie Clinique médico-chirurgicale Tessier

🇫🇷

Valenciennes Cedex, France

Orszagos Koranyi TBC es Pulmonologiai Intezet

🇭🇺

Budapest, Hungary

Bashkirian Republican Clinical Oncology Dispensary

🇷🇺

UFA, Baskortostan, Russian Federation

FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF

🇷🇺

Moscow, Moskovskaja Oblast, Russian Federation

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)

🇷🇺

Saint-Petersburg, Sankt Petersburg, Russian Federation

Medical Clinic "AB Medical group"

🇷🇺

Sankt-peterburg, Sankt Petersburg, Russian Federation

EuroCityClinic

🇷🇺

Sankt-peterburg, Sankt Petersburg, Russian Federation

Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic

🇷🇺

Kazan, Tatarstan, Russian Federation

SBIH Kaluga Region Clinical Oncology Dispensary

🇷🇺

Kaluga, Russian Federation

Tver Regional Oncology Clinical Dispensary

🇷🇺

Tver, Russian Federation

Tawam Hospital

🇦🇪

Al Ain, United Arab Emirates

Clatterbridge Cancer Centre

🇬🇧

Bebington, United Kingdom

Queen Elizabeth Hospital

🇬🇧

London, United Kingdom

East Lancashire Hospitals NHS Trust

🇬🇧

Burnley, United Kingdom

Addenbrookes Hospital

🇬🇧

Cambridge, United Kingdom

Velindre Cancer Centre

🇬🇧

Cardiff, United Kingdom

Royal Surrey County Hospital

🇬🇧

Guildford, United Kingdom

Northwick Park Hospital

🇬🇧

Harrow, United Kingdom

Royal Marsden Hospital

🇬🇧

Kingston upon Thames, United Kingdom

St Bartholomew's Hospital

🇬🇧

London, United Kingdom

Guys and St Thomas Hospital

🇬🇧

London, United Kingdom

Royal Marsden Hospital - Fulham

🇬🇧

London, United Kingdom

Charing Cross Hospital

🇬🇧

London, United Kingdom

The Christie

🇬🇧

Manchester, United Kingdom

James Cook Hospital

🇬🇧

Middlesbrough, United Kingdom

Freeman Hospital

🇬🇧

Newcastle upon Tyne, United Kingdom

Churchill Hospital

🇬🇧

Oxford, United Kingdom

Royal Preston Hospital

🇬🇧

Preston, United Kingdom

Weston Park Hospital

🇬🇧

Sheffield, United Kingdom

Royal Stoke University Hospital

🇬🇧

Stoke on Trent, United Kingdom

Royal Marsden Hospital (Sutton)

🇬🇧

Sutton, United Kingdom

Royal Cornwall Hospital

🇬🇧

Truro, United Kingdom

Pinderfields General Hospital

🇬🇧

Wakefield, United Kingdom

Great Western Hospitals NHS Foundation Trust.

🇬🇧

Wiltshire, United Kingdom

New Cross Hospital

🇬🇧

Wolverhampton, United Kingdom

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