Fat Quality on Blood Lipids and Immune Response
Not Applicable
Completed
- Conditions
- Dietary Prevention
- Interventions
- Other: Food items
- Registration Number
- NCT01679496
- Lead Sponsor
- University of Oslo
- Brief Summary
The purpose of this study is to investigate blood LDL-cholesterol and level of inflammatory markers after intake of food items with different fatty acid composition.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
- hsCRP < 10 mg/L
- total cholesterol 5-7.8 mmol/l(50-70 y)
- total cholesterol 5.0-6.9 mmol/l (30-49 y)
- total cholesterol 5.0-6.1 mmol/l (25-29 y)
- LDL-cholesterol at or above 3.5 mmol/l
- triglycerides at or lower 2.6 mmol/l
- BMI 20-35
- Stable bodyweight last 3 months.
Exclusion Criteria
- Chronic diseases
- fasting glucose > 6.0 mmol/l
- increased ASAT and ALAT
- medications affecting lipidmetabolism and inflammation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Food items Food items Food items low in saturated fat and high in polyunsaturated fat Control food items Food items Food items containing saturated fat and polyunsaturated fat according to a traditional Norwegian diet
- Primary Outcome Measures
Name Time Method Change in LDL-cholesterol Change from baseline after 8 weeks Change in LDL-cholesterol when compared to control diet
Change in total cholesterol Change from baseline after 8 weeks Change in total cholesterol when compared to control diet
- Secondary Outcome Measures
Name Time Method Inflammatory markers in circulation and at gene expression level in PBMC Inflammatory markers are measured at baseline and after 8 weeks intervention in circulation and at gene expression level in PBMC Markers of lipid metabolism at gene expression level in PBMC Markers of lipid metabolism at gene expression level in PBMC is measured at baseline and after 8 weeks of intervention Appetite hormones Appetite hormones is measured at baseline and after 8 weeks of intervention Gut peptides Gut peptides are measured at baseline and after 8 weeks of intervention Metabolites Metabolites are measured at baseline and after 8 weeks of intervention Targeted and untargeted metabolomics will be measured
Whole genome gene expression whole genome gene expression profiles are measured at baseline and after 8 weeks of intervention Microarray
Trial Locations
- Locations (1)
University of Oslo
🇳🇴Oslo, Norway