Natural History Study of Patients With Methylmalonic Acidemia and Propionic Acidemia

Terminated

• Conditions: Propionic Acidemia; Methylmalonic Acidemia
• Interventions: Other: Registry

• Registration Number: NCT05438485
• Lead Sponsor: HemoShear Therapeutics

Brief Summary

The JUMP (Journey to Understand MMA and PA) Study is being conducted by HemoShear Therapeutics and AllStripes, a rare disease online research platform. JUMP is designed to accelerate understanding of the natural course of methylmalonic acidemia (MMA) and propionic acidemia (PA) disease and treatment for families, researchers, clinicians and industry.

The study will collect and provide patient medical record information from multiple institutions for families to access in one place at no cost. AllStripes will remove identifying information like name and address from these medical records and aggregate this data for the HemoShear team to better understand the medical experience and progression of MMA and PA over time. In addition, academic researchers, healthcare practitioners and patient advocacy groups can apply to use the collective patient community data to answer specific research questions at no cost.

HemoShear is collecting natural history data on MMA and PA because the company needs insight into the real-world experience of many patients to better understand the disease and be able to scientifically demonstrate whether the potential new treatment they are developing is effective in improving outcomes.

This natural history study will include retrospective and prospective components. The retrospective component will consist of data abstracted from primarily electronic health records (eHR) and some paper records. The prospective component will include ongoing collection of medical records from enrolled participants, and participants may opt in to complete health-related questionnaires and an optional genetic testing sub-study.

After signing informed consent, participants or their legal guardians will grant permission to AllStripes to collect their health records for data abstraction.

Participants may opt into an optional no cost genetic testing sub-study. The JUMP (Journey to Understand MMA and PA) sub-study will help assess whether the genetic variant of the affected person may relate to disease severity and treatment response. Getting genetic testing will enable participants to understand the genetic mutation that causes their type of methylmalonic acidemia (MMA) or propionic acidemia (PA). Knowing the genetic mutations (whether from the MMUT, MMAA or MMAB gene or PCCA or PCCB) can help the impacted person, their caregivers and healthcare professionals understand the potential course of disease and select approaches to better manage the disease. The additional information will enable HemoShear and AllStripes to understand whether different genetic variants impact the disease journey and outcomes.

A separate informed consent will be obtained for participating in the sub-study.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-27
• Study First Submitted: 2022-06-27
• Study First Submitted QC: 2022-06-27
• Study First Posted: 2022-06-30
• Status Verified: 2022-09
• Primary Completion: 2023-10-20
• Study Completion: 2023-10-20
• Last Update Submitted: 2023-12-20
• Last Update Posted: 2023-12-27

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

1. Participant or participant's legal guardian must provide signed, informed eConsent/eAssent prior to releasing health records or performing any study-related procedures.
2. Confirmed diagnosis of MMA or PA.
3. Reside in the US, Canada, or United Kingdom and have all medical records available for abstraction.

Exclusion Criteria

1. Participant or participant's legal guardian is unable to provide complete access to medical records.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Propionic Acidemia (PA)	Registry	Approximately 60 subjects with Propionic Acidemia
Methylmalonic Acidemia (MMA)	Registry	Approximately 60 subjects with Methylmalonic Acidemia

Primary Outcome Measures

Name	Time	Method
Understanding of the natural course of methylmalonic acidemia (MMA) and propionic acidemia (PA) disease and treatment for families, researchers, clinicians and industry.	5 years

Trial Locations

Locations (1)

AllStripes; 🇬🇧 Remote, United Kingdom