NCT07372209已完成不适用
Study of Effects and Underlying Mechanisms of Analgesic Drugs on Inflammatory Pathways and Immune Function in Patients With Endometrial Cancer
Tangshan Maternal and Child Health Hospital1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2025年10月1日最近更新:
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- blood pressure
研究概览
简要总结
to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 18-65 years;
- •American Society of Anesthesiologists (ASA) physical status I-II;
- •Elective gynecologic laparoscopic surgery;
- •Expected operative time 60-180 minutes;
排除标准
- •Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia);
- •Uncontrolled hypertension;
- •Severe renal or hepatic dysfunction;
- •Severe mental disorder or psychiatric illness;
- •Known allergy or hypersensitivity to opioids;
- •History of alcohol abuse or opioid addiction;
- •Anticipated difficult airway;
- •Pregnancy or lactation;
研究组 & 干预措施
sufentanil
Active Comparator
0.5μg/kg of sufentanil was used for anesthesia induction
干预措施: Sufentanil (Drug)
Oliceridine
Experimental
0.13mg/kg oliceridine was used for anesthesia induction
干预措施: Oliceridine (Drug)
结局指标
主要结局
blood pressure
时间窗: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation
heart beat
时间窗: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation
次要结局
- adverse reactions(from the administration of sufentanil or oliceridine until discharge from the post-anesthesia care unit (PACU))
研究者
Yu Zhang
principle nvestigator
Tangshan Maternal and Child Health Hospital
研究点 (1)
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