Dexmedetomidine Enhancing the Recovery After Cardiac Surgery

Not Applicable

Completed

• Conditions: Post-cardiac Surgery
• Interventions: Drug: Dexmedetomidine; Drug: Fentanyl; Drug: Lidocain

• Registration Number: NCT06907277
• Lead Sponsor: Benha University

Brief Summary

Enhanced Recovery After Surgery (ERAS) aims to facilitate a quicker and smoother recovery period following surgical procedures. The implementation of these protocols may lead to patients returning to their daily activities sooner, experiencing greater satisfaction with their care, and potentially encountering fewer complications, ultimately contributing to shorter hospital stays. However, a common challenge in the postoperative phase is postoperative delirium(POD). This complication can lead to both immediate and long-term cognitive impairments, negatively impact overall health outcomes, and increase the financial burden on the healthcare system. Interestingly, dexmedetomidine, known as DXM, is a medication that selectively targets certain receptors in the brain and offers sedative properties with minimal impact on breathing. This characteristic is noteworthy because it may help regulate sleep patterns and support the preservation of cognitive function during the recovery period.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-08-30
• Primary Completion: 2024-12-01
• Study Completion: 2025-01-31
• Status Verified: 2025-03
• Study First Submitted: 2025-03-26
• Study First Submitted QC: 2025-03-26
• Last Update Submitted: 2025-03-26
• Study First Posted: 2025-04-02
• Last Update Posted: 2025-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Patients of American Society of Anesthesiologists Classification (ASA) grade II-III;
• Patients who were planned to have Coronary Artery Bypass Graft (CABG);
• Patients were free of exclusion criteria.

Exclusion Criteria

• Patients with preoperative high risk for getting Post Operative Delirium or sleep disorders,
• Patients with American Society of Anesthesiologists Classification (ASA) grade>III;
• Patients with heart failure, left ventricle ejection fraction of <25%,
• Patients with uncontrolled diabetes mellitus, coagulopathy, or history of uncompensated renal or hepatic diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group D	Dexmedetomidine	-
Group D	Lidocain	-
Group F	Fentanyl	-

Primary Outcome Measures

Name	Time	Method
Significant Enhancement of Post Operative Recovery Levels After Dexmedetomidine Administration in Cardiac Surgery.	3 months	Post-operative recovery was measured on 3 levels: Confusion, Sleep Quality, and Delirium.; The study focused primarily on postoperative delirium through the Delirium Index, a 7-item questionnaire that graded the severity of delirium in patients with or without dementia. These seven items assess disorders of attention, thought, consciousness, orientation, memory, perception, and psychomotor activity. Each item is scored on a 0-3 scale, with zero indicating the absence of disturbance, while 1-3 indicates mild, moderate, and severe disturbance of the assessed function for a total score ranging between 0 and 21, and higher scores indicate higher delirium severity.

Trial Locations

Locations (1)

Benha University; 🇪🇬 Banhā, El Qalyoubia, Egypt