Hyperglycemia, Exercise, and Endothelial Function

Not Applicable

Completed

• Conditions: Hyperglycemia; Endothelial Function

• Registration Number: NCT03651713
• Lead Sponsor: University of Iowa

Brief Summary

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Detailed Description

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Study Timeline

• Study First Submitted: 2018-08-22
• Study First Submitted QC: 2018-08-27
• Study First Posted: 2018-08-29
• Study Start: 2018-10-15
• Primary Completion: 2019-10-21
• Study Completion: 2019-10-21
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-23
• Last Update Posted: 2020-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• Healthy young men 18-35 years of age.

Exclusion Criteria

• Hypertension,
• Hyperlipidemia,
• Smoking,
• Heart disease,
• Chest pain upon exertion,
• Previous heart surgeries or history of arrhythmias,
• Diabetes,
• Obesity (body mass index ≥30kg/m2),
• Kidney disease,
• Pulmonary disease,
• Autonomic disorders,
• Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
• Current use of medications which influence outcome measures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Vascular Endothelial Function	Before and after the seven-day intervention in both groups.	Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.

Secondary Outcome Measures

Name	Time	Method
Central Blood Pressure	Before and after the seven-day intervention in both groups.	Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions.

Trial Locations

Locations (1)

Medical Education Building; 🇺🇸 Iowa City, Iowa, United States