Effect of Short-Term Glucose Loading on Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Change in Vascular Endothelial Function
研究概览
简要总结
The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.
详细描述
Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy young men 18-35 years of age.
排除标准
- •Hypertension,
- •Hyperlipidemia,
- •Heart disease,
- •Chest pain upon exertion,
- •Previous heart surgeries or history of arrhythmias,
- •Diabetes,
- •Obesity (body mass index ≥30kg/m2),
- •Kidney disease,
- •Pulmonary disease,
- •Autonomic disorders,
- •Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
- •Current use of medications which influence outcome measures
研究组 & 干预措施
GLU+EX
Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.
干预措施: GLU+EX (Behavioral)
GLU
Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.
干预措施: GLU (Dietary Supplement)
结局指标
主要结局
Change in Vascular Endothelial Function
时间窗: Before and after the seven-day intervention in both groups.
Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.
次要结局
- Central Blood Pressure(Before and after the seven-day intervention in both groups.)
研究者
Darren P Casey
Assistant Professor
University of Iowa