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Clinical Trials/NCT02840396
NCT02840396
Completed
Not Applicable

Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language

Jean-Marie Annoni1 site in 1 country22 target enrollmentMarch 2016
ConditionsLanguage

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Language
Sponsor
Jean-Marie Annoni
Enrollment
22
Locations
1
Primary Endpoint
Language production
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

The purpose of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on language production.

Detailed Description

Background: Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011). Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi \& Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access. Aim and procedure: The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production. Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.

Registry
clinicaltrials.gov
Start Date
March 2016
End Date
July 2017
Last Updated
6 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Jean-Marie Annoni
Responsible Party
Sponsor Investigator
Principal Investigator

Jean-Marie Annoni

Prof. Dr. med.

University of Fribourg

Eligibility Criteria

Inclusion Criteria

  • L1 French, knowledge of English as a foreign language
  • 18-45 years of age
  • Right-handedness

Exclusion Criteria

  • epilepsy /family history of epilepsy
  • brain surgery, traumatic brain injuries
  • cardiac pacemaker, metallic objects in the body
  • history of neurological diseases or psychiatric disorders
  • drug use (alcohol, psychoactive medication)
  • developmental language disorder

Outcomes

Primary Outcomes

Language production

Time Frame: within 30 mins after rTMS/sham rTMS

Picture naming task and word translation task

Secondary Outcomes

  • non-verbal executive functions task(within 30 mins after rTMS/sham rTMS)

Study Sites (1)

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