The effect of methadone maintenance treatment on cognitive functions in people suffering from opiate dependency

Not Applicable

• Conditions: People suffering from opiate dependency; Methadome maintenance treatment; Cognitive functions; Neurological - Other neurological disorders; Mental Health - Addiction

• Registration Number: ACTRN12610000536066
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-07-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Inclusion criteria for the MM group include:
1. aged between18 and 45 inclusive
2. with a history of heroin/ other opiate dependence
3. being stabilised in their current methadone dose for at least 2 weeks
4. basic English literacy skills
5. able to provide written consent

Inclusion criteria for the current opiate-dependent users include:
1. aged between18 and 45 inclusive
2. met the Diagnostic and Statistical Manual of Mental Disorders - 4th Edition (DSM-IV) criteria for heroin/other opiate dependence in the 1 year period prior to the study
3. basic English literacy skills
4. able to provide written consent

Inclusion criteria for health controls include:
1. aged between18 and 45 inclusive
2. no history of substance abuse
3. basic English literacy skills
4. able to provide written consent

Exclusion Criteria

Exclusionary criteria for all participants include current or lifetime history of psychotic disorder, depression, cardiac disease, endocrine disorder, head trauma, or neurological disease.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Memory measured by psychometric tasks, such as memory recall, Span of Visual Memory, Number of Memory, Reverse Number Memory, from a standardised Test Battery[Baseline]

Secondary Outcome Measures

Name	Time	Method
Attention measured by psychometric tasks, such as spot the real word and Switching of Attention, from a standardised Test Battery[Baseline];Processing speed measured by psychometric tasks, such as motor tapping, choice reaction, timing, from a standardised Test Battery[Baseline]