The effects of phenylephrine on oxygenation during one-lung ventilation; a randomized, double-blind, cross-over study
Not Applicable
- Conditions
- Adult patients undergoing elective thoracic surgery in the lateral decubitus position with at least 70 minutes of one-lung ventilation
- Registration Number
- JPRN-UMIN000024317
- Lead Sponsor
- Graduate School of Medical and Dental Sciences, Kagoshima University
- Brief Summary
Twenty-nine patients were analyzed. Although phenylephrine infusion significantly increased mean arterial pressure (P < 0.001), arterial partial pressure of oxygen did not differ between the two timepoints (P = 0.19). There was no carryover effect in arterial partial pressure of oxygen (P = 0.14). Phenylephrine infusion significantly decreased heart rate (P = 0.02) and pulse pressure variation (P < 0.001).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
Not provided
Exclusion Criteria
History of stroke, uncompensated cardiac disease, or arrhythmias
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Arterial oxygen pressure after intervention
- Secondary Outcome Measures
Name Time Method Mean Arterial Pressure, HeartRate, Pulse Pressure Variation, Perfusion Index, and Difference between Bladder Temperature and Skin Temperature