NCT04214145已完成不适用
The Effect of Phenylephrine, Norepinephrine and Vasopressin on Cerebral Oxygentaion During Off Pump CABG: A Pilot Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Cerebral oxygen saturation (%)
研究概览
简要总结
The purpose of this study is to analyze the changes in cerebral oxygen saturation during the use of three vasopressors, phenylephrine, norepinephrine, and vasopressin, which are currently used during coronary artery bypass grafting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing off pump coronary artery bypass.
排除标准
- •Patient refusal
- •Preoperative vasopressor use
- •Preoperative mechanical circulatory support
- •Concurrent cerebrovascular or head and neck surgery
- •Technical difficulty of measuring brain oxygen saturation
- •Redo coronary artery bypass surgery
研究组 & 干预措施
Phenylephrine
Experimental
干预措施: Phenylephrine (Drug)
Norepinephrine
Experimental
干预措施: Norepinephrine (Drug)
Vasopressin
Experimental
干预措施: Vasopressin (Drug)
结局指标
主要结局
Cerebral oxygen saturation (%)
时间窗: during surgery
continuous monitoring of cerebral oxygen saturation during surgery
次要结局
- NGAL(during surgery, at ICU admission, 24 hours / 48 hours after ICU admission)
- MACCE(until 1 year after surgery)
- blood pressure(during surgery)
- heart rate(during surgery)
- cardiac index(during surgery)
- Total amount of infused drug(during surgery)
- Input/output(during surgery)
- Sublingual microscopy(1) After induction, 2) lateral wall or posterior wall anastomosis (if possible) 3) skin closure)
- Vascular occlusion test(1) After induction, 2) lateral wall or posterior wall anastomosis (if possible) 3) skin closure)
- Troponin I(during surgery, at ICU admission, 24 hours / 48 hours after ICU admission)
- lactate(during surgery, at ICU admission, 24 hours / 48 hours after ICU admission)
- creatinine(during surgery, at ICU admission, 24 hours / 48 hours after ICU admission)
- albumin(during surgery, at ICU admission, 24 hours / 48 hours after ICU admission)
- AKI/RRT(until 1 year after surgery)
研究者
Yunseok Jeon
Professor
Seoul National University Hospital
研究点 (1)
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