Combination of NHF and Nebulizer on Lung Function in COPD

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Device: Nasal high flow (NHF); Device: Nebulizer

• Registration Number: NCT02885103
• Lead Sponsor: University of Leipzig

Brief Summary

This study will prove to concept of effectiveness of NHF in combination with a nebulizer on reversibility of lung function in COPD patients.

Detailed Description

Patients will inhale on day 1 with a nebulizer and on another day with combination of nebulizer an NHF in a randomised order.

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2016-08-22
• Study First Submitted QC: 2016-08-25
• Study First Posted: 2016-08-31
• Primary Completion: 2017-11
• Study Completion: 2017-11
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-25
• Last Update Posted: 2018-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• stable disease
• COPD

Exclusion Criteria

• exacerbation
• right heart decompensation
• acute respiratory insufficiency
• acute disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
inhalation with nebulizer and NHF	Nasal high flow (NHF)	inhalation with combination of nebulizer and nasal high flow (NHF) via nasal cavity
inhalation with nebulizer	Nebulizer	inhalation with an nebulizer via mouth

Primary Outcome Measures

Name	Time	Method
changes in forced expiratory volume in 1s (FEV1)	45 minutes	litre
changes in breath way resistance (Rtot)	45 min

Trial Locations

Locations (1)

Department of Respiratory Medicine; 🇩🇪 Leipzig, Sachsen, Germany