Carbetocin versus Oxytocin for the Prevention of Postpartum Hemorrhage in Hypertensive Pregnant Wome
- Conditions
- Pregnancy and Childbirth
- Registration Number
- PACTR201909807831604
- Lead Sponsor
- faculty of medicine suez canal university
- Brief Summary
Both drugs were associated with a statistically significant decrease in blood pressure. Hemoglobin decreased significantly among the oxytocin group (pre-operative hemoglobin 12.1 ± 3.8 versus post-operative 10.4 ± 1.1). Blood loss was significantly more among the oxytocin group (424.75 ± 182.59 in carbetocin group versus 679.5 ± 200.25 in the oxytocin group, p- value <0.001). Nausea, vomiting, and sweating were reported more significantly in oxytocin group patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 160
women aged 18-35 years
with term singleton pregnancy
prepared for elective lower segment CS at gestational age of = 37 weeks wit
h diagnosed hypertensive disorders in pregnancy.
risk factors for excessive blood loss during the surgery (placenta previa,
twin pregnancy or presence of uterine fibroid),
a history of thromboembolic disorders
cases suffering from chronic medical diseases (cardiac, hepatic, renal).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •Estimated amount of blood loss.<br>•Incidence and amount of blood transfusion.<br>•Hemoglobin and hematocrit changes pre-and post delivery.<br>•Use of further ecobolics.<br>
- Secondary Outcome Measures
Name Time Method •Vital signs during and after delivery.<br>•Time of discharge from hospital. <br>•Complications post-delivery (fever, Disseminated Intravascular Coagulation (DIC), maternal infection, ICU admission and cesarean hysterectomy). <br>•Uterine tone and adverse effects.<br>•Neonatal weight.<br>•Neonatal Apgar score.<br>•Neonatal admission to neonatal intensive care.<br>