The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population
Phase 4
- Conditions
- Hypertension
- Interventions
- Drug: anti-hypertensive medication
- Registration Number
- NCT00966199
- Lead Sponsor
- Radboud University Medical Center
- Brief Summary
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Age >= 70 years
- Systolic office blood pressure >= 160 mmHg
- Systolic home blood pressure >= 155 mmHg
Exclusion Criteria
- Diabetes Mellitus
- Atrial fibrillation
- Dementia
- Renal failure requiring dialysis
- Life expectancy of less than 1 year
- Disabling stroke
- Contraindication for MRI or anti-hypertensive medication
- Systolic blood pressure > 220 mmHg
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Hypertensive elderly anti-hypertensive medication community dwelling hypertensive elderly from general practices
- Primary Outcome Measures
Name Time Method Cerebral blood flow T1, 8-12 weeks of treatment, T2
- Secondary Outcome Measures
Name Time Method Cognitive functioning assessed by neuropsychological testing T1, 8-12 weeks of treatment, T2-3
Trial Locations
- Locations (1)
Radboud University
🇳🇱Nijmegen, Gelderland, Netherlands