Incidence and Clinical Relevance of Perioperative Elevation of Troponin I and N- Terminal Pro-Brain Natriuretic Peptide in Patients Undergoing Lung Resection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 475
- 试验地点
- 1
- 主要终点
- NT-proBNP perioperative changes
研究概览
简要总结
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.
详细描述
Objectives: To evaluate the incidence and magnitude of perioperative N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (Tn I) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. Methodology: Prospective, multicenter, observational cohort study in patients >45 years undergoing elective thoracic surgery for lung resection. Cardiac biomarkers Tn I and NT-proBNP will be measured preoperatively and at postoperative days 1 and 2. Risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥45 years old
- •Patients undergoing elective surgery for lung resection
排除标准
- •Patients undergoing urgent, emergent, or nonthoracic surgery
- •Patients or family did not consent to participate
- •Presence of symptoms related with infection or sepsis
- •Patients with a documented history of severe heart failure and/or ejection fraction lower than 30%
结局指标
主要结局
NT-proBNP perioperative changes
时间窗: Change from baseline NT-proBNP at two-days after surgery
Perioperative change in NT-Pro-Brain Natriuretic Peptide (NT-proBNP) levels in patients undergoing pulmonary resection. Cutt-of values will be NT-proBNP ≥ 300 pg/ml pg/ml
TnI perioperative changes
时间窗: Change from baseline TnI at two-days after surgery
Perioperative changes in high-sensitivity troponin I (TnI) levels in patients undergoing pulmonary resection. Cutt-of values will be TnI ≥45 ng/L
Major cardiovascular complications
时间窗: 30-days after surgery
Postoperative non-fatal cardiac arrest, acute myocardial infarction, angina, congestive heart failure, new clinically relevant cardiac arrhythmia, cardiovascular death
次要结局
未报告次要终点