Lung Perfusion With Oxygenated Blood During Aortic Clamping
Not Applicable
Completed
- Conditions
- Postoperative Pulmonary Dysfunction
- Registration Number
- NCT01186510
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Brief Summary
Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion.
Aim of the study: To evaluate the protective effect of continuous pulmonary perfusion with oxygenated blood during aortic crossclamping on the inflammatory response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Age 18-80 ys
- Cardiopulmonary bypass procedure
- FEV1 <80%
- COPD >II
Exclusion Criteria
- Emergency cases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Inflammatory marker 5 days
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie lung injury after cardiopulmonary bypass and aortic crossclamping?
How does continuous pulmonary perfusion compare to standard CPB in reducing postoperative pulmonary dysfunction?
Are there specific biomarkers that predict inflammatory response severity after cardiac surgery with CPB?
What adverse events are associated with oxygenated lung perfusion during aortic crossclamping and how are they managed?
What alternative strategies or compounds have been explored for mitigating CPB-induced pulmonary inflammation?
Trial Locations
- Locations (1)
Goethe University
🇩🇪Frankfurt am Main, Germany
Goethe University🇩🇪Frankfurt am Main, Germany