Acute Lung Injury After Cardiac Surgery: Pathogenesis

Aalborg University Hospital0 sites50 target enrollmentSeptember 2008

ConditionsAcute Lung Injury Metabolic Disturbances Inflammation Coagulation; Intravascular Postoperative; Dysfunction Following Cardiac Surgery

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Lung Injury
Sponsor: Aalborg University Hospital
Enrollment: 50
Primary Endpoint: Acute lung injury measured as the fraction of partial pressure of oxygen divided by the fraction of inspired oxygen
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.

Detailed Description

Acute lung injury after cardiac surgery is a common complication. The pathophysiology is complex and still not fully elucidate. No specific biomarkers are identified and the diagnosis is solely based on impaired oxygenation. The purpose of the present study is to identify biomarkers of inflammation and coagulation in blood withdrawn simultaneous from the pulmonary artery and the left atrium during surgery and up to 20 hours after weaning from cardiopulmonary bypass.

Registry

clinicaltrials.gov

Start Date

September 2008

End Date

March 2009

Last Updated

10 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Aalborg University Hospital

Responsible Party

Principal Investigator

Bodil Steen Rasmussen

Professor, PhD

Aalborg University Hospital

Eligibility Criteria

Inclusion Criteria

•Elective surgery
•In treatment with statins

Exclusion Criteria

•Acute surgery
•Valve replacement
•In treatment with immunodepressive drugs

Outcomes

Primary Outcomes

Acute lung injury measured as the fraction of partial pressure of oxygen divided by the fraction of inspired oxygen

Time Frame: Evaluated 72 hours after weaning from cardiopulmonary bypass (CPB)

Arterial blood gas analysis

Secondary Outcomes

Interleukin-1beta(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
D-dimer(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB)
Interleukin-2(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Interleukin-4(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Interleukin-6(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Interleukin-8(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Interleukin-10(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Tumor necroting factor-alpha(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Thrombin-antithrombin complexes(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB)
Plasmin-antiplasmin complexes(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB)
Interferon-gamma(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Granulocyte-macrophage colony-stimulating factor(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)
Thrombin Fragment 1.2(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB)
Metabolomics(The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB)