Acute Lung Injury After Cardiac Surgery: Pathogenesis
- Conditions
- InflammationCoagulation; IntravascularPostoperative; Dysfunction Following Cardiac SurgeryAcute Lung InjuryMetabolic Disturbances
- Registration Number
- NCT02475694
- Lead Sponsor
- Aalborg University Hospital
- Brief Summary
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
- Detailed Description
Acute lung injury after cardiac surgery is a common complication. The pathophysiology is complex and still not fully elucidate. No specific biomarkers are identified and the diagnosis is solely based on impaired oxygenation.
The purpose of the present study is to identify biomarkers of inflammation and coagulation in blood withdrawn simultaneous from the pulmonary artery and the left atrium during surgery and up to 20 hours after weaning from cardiopulmonary bypass.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Elective surgery
- CABG
- In treatment with statins
- Acute surgery
- Valve replacement
- In treatment with immunodepressive drugs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute lung injury measured as the fraction of partial pressure of oxygen divided by the fraction of inspired oxygen Evaluated 72 hours after weaning from cardiopulmonary bypass (CPB) Arterial blood gas analysis
- Secondary Outcome Measures
Name Time Method Interleukin-1beta The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
D-dimer The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB Measured in blood samples from pulmonary artery and left atrium
Interleukin-2 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Interleukin-4 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Interleukin-6 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Interleukin-8 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Interleukin-10 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Tumor necroting factor-alpha The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Thrombin-antithrombin complexes The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB Measured in blood samples from pulmonary artery and left atrium
Plasmin-antiplasmin complexes The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB Measured in blood samples from pulmonary artery and left atrium
Interferon-gamma The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Granulocyte-macrophage colony-stimulating factor The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Measured in blood samples from radial artery, pulmonary artery and left atrium
Thrombin Fragment 1.2 The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB Measured in blood samples from pulmonary artery and left atrium
Metabolomics The day before surgery; the day of surgery with measurement just before connecting to , immediately after weaning from CPB, 2, 4, 8, 16 and 20 hours after weaning from CPB; and exactly 48 and 72 hours after weaning from CPB Metabolomics using the NMR-technique in blood samples from radial artery, pulmonary artery and left atrium