Association Study of Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery With Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 107
- 试验地点
- 1
- 主要终点
- Acute lung injury after cardiac surgery with cardiopulmonary bypass
研究概览
简要总结
Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost. Currently available predictors of acute lung injury after cardiac surgery are still limited within clinical data. Several genetic polymorphism of inflammatory mediators have been reported to be associated with severity of sepsis and ARDS, but the association of these inflammatory polymorphism and acute lung injury after cardiac surgery has never been reported. This study is performed to investigate the association of genetic polymorphisms including TNF -308A/G, IL-10 -1082A/G and IL-6 -572C/G and postoperative lung injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chinese Han unrelated population
- •adult patients
- •undergoing elective cardiac surgery with CPB
排除标准
- •malignant tumor
- •autoimmune disease, immunodeficiency or immunosuppressive therapy
- •chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A)
- •COPD, tuberculosis or other chronic pulmonary diseases
- •anemia with hemoglobin lower than 90mmHg
- •bleeding disorders
- •postoperative pericardial tamponade requiring re-operation
- •postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.
结局指标
主要结局
Acute lung injury after cardiac surgery with cardiopulmonary bypass
时间窗: 24h after surgery
次要结局
- circulating level of CRP, TNF-alpha, IL-10, IL-6; APACHE Ⅱ score; postoperative kidney injury, duration of ventilation, ICU stay and hospitalization; death in 28 days(24h and 1 month after surgery)