Association of ghrelin and leptin in cardiovascular autonomic dysfunction in patients with primary dysautonomia.

Not Applicable

• Conditions: autonomic failure such as Parkinson' s disease

• Registration Number: JPRN-UMIN000017036
• Lead Sponsor: agoya University Graduate School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-03
• Study Completion: 2016-02-29
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Individuals with diabetes mellitus, any known heart disease, hypertension, Cussing syndrome, rheumatism, difficulty in blood drawing, or other neurological disorders were excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We evaluate the relation with these hormones and cardiac parameters such as orthstatic hypotention, postprandial hypotension, CVR-R, and cardiac MIBG. The first two years, we collect the date of about 50 patients and 25 normal controls. If there exist any relation with the secretion and cardiovascular dysautonomia, we will follow the patients and observe whether the progression of the disease have some relation with these hormons.

Secondary Outcome Measures

Name	Time	Method
We also evaluate the relation with drug, smell function, MMSE, and UPDRS.