Effect of the use of beneficial bacteria on the intestinal microbiota and on nutritional, biochemical and clinical indicators of patients who underwent stomach reduction surgery
Not Applicable
Recruiting
- Conditions
- Obesity, Bariatric surgery, Gastrointestinal Microbiome, Dysbiosis
- Registration Number
- RBR-4sqhppp
- Lead Sponsor
- niversidade Federal do Paraná
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Adult patients (18-60 years old); both sexes; who underwent Roux-en-Y Gastric Bypass 1 year ago and signed the IC; Of these, for the intervention with probiotics, only patients who report at least 1 gastrointestinal symptom of moderate to severe intensity in the GSRS questionnaire will be included.
Exclusion Criteria
Patients undergoing other surgical techniques will be excluded; those who underwent reoperation or surgical correction; who used antibiotics during the study period or who did not use the placebo / probiotic for 12 days or more (20%) during each phase of the study.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It is expected to observe a reduction of 1 point in the score of the moderate (s) symptom (s) reported in the GSRS questionnaire in patients treated with probiotics.
- Secondary Outcome Measures
Name Time Method It is expected to observe in the patients treated with probiotics the resolution of bacterial overgrowth of the small intestine, by reducing the ppm of expired hydrogen, verified by the spirometry method; alteration of the intestinal microbiota evaluated by the r16S method of genetic sequencing of bacteria from feces; improvement of the profile of the metabolites produced by the intestinal microbiota, evaluated by the blood plasma nuclear magnetic resonance methodology; improvement of the biochemical profile assessed from the blood test performed.