The efficacy of probiotics on intestinal flora for surgical baby
Phase 4
Recruiting
- Conditions
- congenital anomaly
- Registration Number
- JPRN-UMIN000033805
- Lead Sponsor
- Juntendo University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1) The patient was considered prenatally diagnosed as requiring surgery but was aborted or in utero fetal death. 2) Patients who underwent surgery after 28 days of age
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cytokines in blood (IL6, IL10, IL12, IL18, IFNg), IgG, IgA, IgE are measured. DNA analysis of intestinal microflora in feces with next generation sequencer. For each item, compare with neonatal surgery case / non-surgical case. Blood and fecal samples should be taken at the following schedule. (Surgery case: at birth, immediately before surgery, immediately after surgery, 1st day after surgery, 3rd day, 7th day Non-surgical case: at birth, 1st day after birth, 3rd day, 7th day) We will examine the correlation between postoperative clinical course and the above results.
- Secondary Outcome Measures
Name Time Method