The effect of probiotics on gastrointestinal symptoms during endurance exercise and exercise performance in relation to the composition of the gut microbiota/metabolites.
- Conditions
- veranderingen in samenstelling darmmicrobioom/metabolieten en voorkomen maagdarmklachten bij gezonde personengastrointestinal symptoms - gastrointestinal distress
- Registration Number
- NL-OMON48006
- Lead Sponsor
- Hogeschool Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
healthy male (No females because: menstrual cycle of women is an additional
confounder of the possible relationship between intestinal microbiota and the
development of gastrointestinal symptoms during endurance exertion. And to
exclude possible gender-related effects of probiotics on exercise-induced
gastrointestinal symptoms, because females show less effect on the incidence
and severity of upper respiratory tract infections, this might also be the case
for probiotics and the GI symptoms).
18-45 years old;
Dutch descent; Only men of Dutch descent (which is both parents from Dutch
descent) are included, because ethnicity influences the gut microbiota;
maximal oxygen uptake (VO2max) * 45 mL*kg-1*min-1 (based on an incremental
exercise test you are considered recreationally trained);
an average training frequency of at least three times per week;
a low risk profile based on a health-history form;
regular occurrence of exercise-induced gastrointestinal symptoms.
smoking;
a diagnosis of gastrointestinal disorders (e.g. Crohn*s disease, celiac
disease, diagnosed with irritable bowel syndrome);
use of antidepressants in the 6 months prior to the start of the study;
use of antibiotics, antivirals, antifungals, antiparasitic agents,
prebiotics/probiotics supplements in the 6 months prior to the start of the
study.
use of probiotic food products like probiotic yoghurt and/or probiotic (dairy)
drinks in the two weeks prior to the start of the study and during the study.
Examples of these products are: Actimel, Activia, Kefir, Yakult. Prebiotic
supplements and probiotic supplements are also not allowed.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study objective is to study whether fourteen weeks of supplementation<br /><br>with a probiotics supplement can influence the occurrence and severity of<br /><br>gastrointestinal symptoms during and directly after endurance exercise and the<br /><br>running performance in recreationally trained endurance athletes. Performance<br /><br>is: distance in km (on a 30 minute running time trial, preceded by two times 30<br /><br>minutes submaximal running) and maximum speed in km/h and VO2max (on a maximal<br /><br>incremental running exercise test).</p><br>
- Secondary Outcome Measures
Name Time Method