A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04
- Conditions
- GastroparesisDiabetes Mellitus
- Interventions
- Drug: Placebo
- Registration Number
- NCT03383146
- Lead Sponsor
- Allergan
- Brief Summary
A 52-week study to compare the efficacy of relamorelin with that of placebo in participants with diabetic gastroparesis (DG) with respect to the core signs and symptoms of diabetic gastroparesis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 450
Two different groups of participants may enter into the study:
-
Rollover Participants
Participants who were not randomization-eligible at the end of the Run-in Period of lead-in studies RLM-MD-01 (NCT03285308) or RLM-MD-02 (NCT03426345) are eligible to be randomized in the study if all of the following criteria apply:
•In the lead-in studies, participants must have met all screening visit and Run-in Period criteria for randomization into the Treatment Period (including compliance with dosing, entry of diary data into the Diabetic Gastroparesis Symptom Severity Diary (DGSSD)) except that:
- They had zero vomiting episodes and an average daily Diabetic Gastroparesis Symptom Severity Score (DGSSS) of ≥12 at the end of the lead-in study Run-in Period, as reported using the electronic hand-held device; OR
- They had vomiting episodes and an average daily DGSSS of ≥12 but <16 at the end of the lead-in study Run-in Period, as reported using the electronic hand-held device
-
De Novo Participants
- Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) of at least 5 years' duration, with controlled and stable blood glucose levels and hemoglobin A1c (HBA1c) ≤11%
- DG defined as at least a 3-month history prior to Screening of symptoms (one of which must be nausea) on an ongoing basis that are suggestive of gastroparesis (GP) (e.g., nausea, abdominal pain, postprandial fullness, bloating, vomiting, and early satiety)
- Compliance with the entry of data into the hand-held electronic device during the Run-in Period
- Compliance with administration of subcutaneous (SC) twice daily injections during the Run-in Period
- The average of the daily DGSSS from the 2-week, Run-in Period must be ≥12
-
Both Rollover and De Novo Participants
•Participants with a known allergy or hypersensitivity to the study treatments and their excipients (i.e., mannitol or phenol)
-
Rollover Participants
•Participants will be excluded from this study if any of the lead-in study exclusion criteria apply at the Screening Visit and at the end of the Run-in Period for randomization into the Treatment Period of studies RLM-MD-01 and RLM-MD-02, except as specified in the inclusion criteria
-
De Novo Participants
- History of anorexia nervosa, binge-eating, bulimia, or other eating disorder within 5 years of the Screening Visit
- History of intestinal malabsorption or pancreatic exocrine insufficiency
- History of belching disorders, other nausea and vomiting disorders
- Gastric or duodenal ulcer within 3 months of Screening
- History of malignancy in the 3 years prior to Screening, except for adequately treated basal cell or squamous cell skin cancer, or in situ cervical cancer
- Currently receiving parenteral feeding or presence of a nasogastric or other enteral tube for feeding or decompression
- Use of metoclopramide, domperidone, prucalopride, macrolide antibiotics (e.g., erythromycin, clarithromycin, azithromycin), or other drugs considered to be GI promotility agents for at least 10 days prior to the start of the Run-in Period
- Currently taking opiates, or expecting to use opiates during the course of the clinical study
- Treatment with glucagon-like peptide-1 (GLP-1) agonist for at least 6 weeks prior to the start of the Run-in Period
- History of pyloric injection of botulinum toxin within 6 months of screening
- History of gastric surgery such as fundoplication, gastrectomy, gastric pacemaker placement, vagotomy, or bariatric procedure (a history of diagnostic endoscopy is not exclusionary)
- Randomization in any previous study in which relamorelin was a treatment
- Allergic to, or intolerant of egg, wheat, milk, or algae, as these are components of the gastric emptying breath test (GEBT) study meal
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo injected subcutaneously twice daily for up to 52 weeks. De novo (New) participants, who did not participate in the previous relamorelin studies, began the study with a 2-week placebo run-in. Relamorelin 10 μg Relamorelin Relamorelin 10 micrograms (μg) injected subcutaneously twice daily for up to 52 weeks. De novo (New) participants, who did not participate in the previous relamorelin studies, began the study with a 2-week placebo run-in.
- Primary Outcome Measures
Name Time Method Change From Baseline to Week 12 in the Weekly Diabetic Gastroparesis Symptom Severity Score (DGSSS) Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02 for rollover participants or Day -14 to Day -1 for new participants) to Week 12 of this study Participants assessed the severity of diabetic gastroparesis symptoms daily using the Diabetic Gastroparesis Symptom Severity Diary (DGSSD), recorded in an electronic diary (e-diary). The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period of the previous study or the run-in period of this study for new participants.
Number of Participants With Potential Clinically Significant (PCS) Clinical Laboratory Results Up to 52 weeks Clinical Laboratory tests included Hematology, Chemistry and Urinalysis tests. The investigator determined if the results were clinically significant. Only those categories where at least 1 participant had a non-PCS value at Baseline and met the PCS criterion at least once during postbaseline are reported.
Number of Participants With Clinically Significant Abnormal Electrocardiogram (ECG) Results Up to 52 weeks A standard 12-lead ECG was performed. The investigator determined if the abnormal results were clinically significant.
Change From Baseline to Week 52 in the Weekly Average DGSSS Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02 for rollover participants or Day -14 to Day -1 for new participants) to Week 52 of this study Participants assessed the severity of diabetic gastroparesis symptoms daily using the DGSSD, recorded in an electronic diary (e-diary). The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). The average weekly scores at Week 52 were the average of the DGSSS scores from Week 49 to Week 52. A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period of the previous study or the run-in period of this study for new participants.
Number of Participants With Clinically Meaningful Trends for Vital Signs Up to 52 weeks Vital Signs included assessments of heart rate, respiratory rate, systolic and diastolic blood pressure, and body temperature. The investigator determined if the abnormal results were clinically significant.
Number of Participants With Anti-relamorelin Antibody Testing Results by Visit Baseline (Day 1), Day 84, Day 364, and End of Treatment (Up to Day 364) A blood sample was collected that was sent to a laboratory for an anti-relamorelin antibody screening test. A positive screening test was confirmed by an immunodepletion assay. The number of participants in each of the following categories are reported: Negative Screening Test, Positive Screening Test, Negative Confirmatory Test, and Positive Confirmatory Test at each time point.
Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAE) First dose of study drug to within 30 days of the last dose of study drug (Up to approximately 56 weeks) An adverse event (AE) is any untoward medical occurrence in a patient or clinical study participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of study treatment. A TEAE is an AE that begins or worsens after receiving study drug.
Number of Participants With a ≥1% Increase in Glycosylated Hemoglobin A1c (HbA1c) Up to 52 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (334)
Atlanta Diabetes Associates
🇺🇸Atlanta, Georgia, United States
Endocrinology Research Associates, Inc.
🇺🇸Columbus, Ohio, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
Bhatia Hospital
🇮🇳Mumbai, Maharashtra, India
B. J. Government Medical College and Sassoon General Hospitals
🇮🇳Pune, Maharashtra, India
Eternal Hospital - Diabetology
🇮🇳Jaipur, Rajasthan, India
Noble Hospital
🇮🇳Pune, Maharashtra, India
Marudhar Hospital
🇮🇳Jaipur, Rajasthan, India
Wits Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Diagnamics Inc.
🇺🇸Encinitas, California, United States
Pinnacle Research Group
🇺🇸Anniston, Alabama, United States
VVCRD Research
🇺🇸Garden Grove, California, United States
Upland Clinical Research
🇺🇸Upland, California, United States
Om Research LLC
🇺🇸Lancaster, California, United States
G & L Research, LLC
🇺🇸Foley, Alabama, United States
Kindred Medical Institute for Clinical Trials, LLC
🇺🇸Corona, California, United States
Meritus Center for Clinical Research
🇺🇸Hagerstown, Maryland, United States
MNGI Digestive Health
🇺🇸Coon Rapids, Minnesota, United States
Applied Research Center of Arkansas
🇺🇸Little Rock, Arkansas, United States
Synexus
🇺🇸Pinellas Park, Florida, United States
Stanford Hospital
🇺🇸Palo Alto, California, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Top Medical Research
🇺🇸Cutler Bay, Florida, United States
MediSphere Medical Research Center, LLC
🇺🇸Evansville, Indiana, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
Gastroenterology Associates of Fairfield County, P.C.
🇺🇸Bridgeport, Connecticut, United States
Woodholme Gastroenterology Associates, P.A.
🇺🇸Glen Burnie, Maryland, United States
Metropolitan Gastroenterology Group PC, Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
American Research, LLC
🇺🇸Jeffersonville, Indiana, United States
Frederick Gastroenterology Associates, PA an Elligo Health Research Site
🇺🇸Frederick, Maryland, United States
Diabetes and Endocrinology Consultants, PC
🇺🇸Morehead City, North Carolina, United States
Hometown Urgent Care and Research
🇺🇸Dayton, Ohio, United States
WK Physicians Network
🇺🇸Bossier City, Louisiana, United States
Long Island Gastrointestinal Research Group LLP
🇺🇸Great Neck, New York, United States
Carolinas Healthcare-Charlotte
🇺🇸Charlotte, North Carolina, United States
Cronola LLC
🇺🇸Houma, Louisiana, United States
Diabetes & Endocrinology Associates of Stark County, Inc.
🇺🇸Canton, Ohio, United States
Carolina Digestive Health Associates, PA
🇺🇸Concord, North Carolina, United States
Triad Clinical Trials
🇺🇸Greensboro, North Carolina, United States
Clinsearch
🇺🇸Chattanooga, Tennessee, United States
United Health Services Hospitals, Inc.
🇺🇸Johnson City, New York, United States
PMG Research of Wilmington, LLC
🇺🇸Wilmington, North Carolina, United States
Trial Management Associates, LLC
🇺🇸Wilmington, North Carolina, United States
Gastroenterology Centers of the Midsouth
🇺🇸Germantown, Tennessee, United States
Vidant Multispeciality Clinic - Kinston
🇺🇸Kinston, North Carolina, United States
Advanced Clinical Research
🇺🇸West Jordan, Utah, United States
Gastroenterology Associates, PA
🇺🇸Greenville, South Carolina, United States
Royal Adelaide Hospital - Central Adelaide Local Health Network Incorporated
🇦🇺Adelaide, South Australia, Australia
Frontier Clinical Research, LLC
🇺🇸Smithfield, Pennsylvania, United States
Aventiv Research, Inc.
🇺🇸Columbus, Ohio, United States
Premier Clinical Research d.b.a. STAT Research
🇺🇸Franklin, Ohio, United States
Health Concepts
🇺🇸Rapid City, South Dakota, United States
Hospital Universitário João de Barros Barreto - UFPA
🇧🇷Belem, PA, Brazil
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Ordination
🇦🇹Osterreicher, Steiermark, Austria
KRH Klinikum Siloah
🇩🇪Hannover, Germany
Hospital Universitário Walter Cantídio
🇧🇷Fortaleza, CE, Brazil
Digestive Diseases Centre GASTRO
🇱🇻Riga, Latvia
Verity Research Inc.
🇺🇸Fairfax, Virginia, United States
IPEC-Instituto de Pesquisa Clinica
🇧🇷Sao Paulo, Brazil
SMS Hospital
🇮🇳Jaipur, Rajasthan, India
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
The Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
Clinical Research Hamburg
🇩🇪Hamburg, Germany
Alexandrovska University Hospital
🇧🇬Sofia, Bulgaria
Israelitisches Krankenhaus
🇩🇪Hamburg, Germany
Chonbuk National University Hospital
🇰🇷Jeonju, Jeollabuk-Do, Korea, Republic of
Studienzentrum Schwittay
🇩🇪Böhlen, Saxony, Germany
S R Kalla (SRK) Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Hetenyi Geza Hospital
🇭🇺Szolnok, Jász-Nagykun-Szolnok, Hungary
Sanggye Paik Hospital, Inje University College of Medicine
🇰🇷Seoul, Nowon-gu, Korea, Republic of
Synexus Helderberg Clinical Research Centre
🇿🇦Somerset West, South Africa
Biomedical Research Centre
🇬🇧Nottingham, East Midland, United Kingdom
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Centro de Atención e Investigación en Factores de Riesgo Car
🇲🇽Mexico, Distrito Federal, Mexico
Dioderm Instituto de Investigacion
🇲🇽Durango, Mexico
Watermeyer Clinical Research Site
🇿🇦Pretoria, Val De Grace, South Africa
St. Luke's Medical Center
🇵🇭Quezon City, Philippines
CenterMed Krakow Ltd
🇵🇱Krakow, Malopolska, Poland
MAC Clinical Research
🇬🇧Liverpool, Merseyside, United Kingdom
MAC Clinical Research, GAC House
🇬🇧Manchester, United Kingdom
Vinnytsia Regional Clinical highly specialized Endocrinology Centre
🇺🇦Vinnytsia, Ukraine
MAC Clinical Research, Kaman Court
🇬🇧Blackpool, United Kingdom
MAC Research
🇬🇧Barnsley, United Kingdom
APF Research LLC
🇺🇸Miami, Florida, United States
Advanced Medical Research Institute
🇺🇸Miami, Florida, United States
American Research Institute, Inc
🇺🇸Miami, Florida, United States
Houston Endoscopy and Research Center, Inc.
🇺🇸Houston, Texas, United States
Optimal Research California
🇺🇸San Diego, California, United States
Medical Associates Research Group, Inc
🇺🇸San Diego, California, United States
Quality Medical Research
🇺🇸Nashville, Tennessee, United States
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
Health Science Research Center
🇺🇸Pratt, Kansas, United States
Via Christi Clinic, PA
🇺🇸Wichita, Kansas, United States
Cotton-O'Neil Clinical Research Center - Digestive Health
🇺🇸Topeka, Kansas, United States
WestGlen Gastrointestinal Consultants
🇺🇸Shawnee Mission, Kansas, United States
Centro de Pesquisa Clinica do Brasil
🇧🇷Brasilia, Distrito Federal, Brazil
M.V. Hospital for Diabetes & Diabetes Research Centre
🇮🇳Chennai, Tamil Nadu, India
Arthur Asirvatham Hospital
🇮🇳Madurai, Tamil Nadu, India
Kansas Medical Clinic
🇺🇸Topeka, Kansas, United States
Phoenix Clinical LLC.
🇺🇸Phoenix, Arizona, United States
Núcleo de Pesquisa Clínica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Digestive Health Specialist of the South East
🇺🇸Dothan, Alabama, United States
Avant Research Associates
🇺🇸Huntsville, Alabama, United States
Alabama Medical Group, PC
🇺🇸Mobile, Alabama, United States
Synexus Clinical Research US, Inc.
🇺🇸Murray, Utah, United States
Aurora Care Clinic, LLC
🇺🇸Costa Mesa, California, United States
TriWest Research Associates
🇺🇸El Cajon, California, United States
Palmetto Research, LLC
🇺🇸Hialeah, Florida, United States
Vida Clinical Trials
🇺🇸Homestead, Florida, United States
Savin Medical Group LLC
🇺🇸Miami Lakes, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Florida Research Center, Inc.
🇺🇸Miami, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Sensible Healthcare
🇺🇸Ocoee, Florida, United States
River Birch Research Alliance, LLC
🇺🇸Blue Ridge, Georgia, United States
Gwinnett Research Institute, LLC
🇺🇸Buford, Georgia, United States
Professional Research Network of Kansas, LLC
🇺🇸Wichita, Kansas, United States
St. Elizabeth Healthcare â€" Clinical Research Institute
🇺🇸Erlanger, Kentucky, United States
Vida Clinical Studies
🇺🇸Dearborn, Michigan, United States
Asheville Gastroenterology Associates
🇺🇸Asheville, North Carolina, United States
PMG Research Salisbury
🇺🇸Salisbury, North Carolina, United States
Synexus Clinical Research US - Cincinnati
🇺🇸Cincinnati, Ohio, United States
Preferred Primary Care Physicians, Inc.
🇺🇸Pittsburgh, Pennsylvania, United States
Allegheny Endocrinology Associates
🇺🇸Pittsburgh, Pennsylvania, United States
Centennial Health-Synexus
🇺🇸Oklahoma City, Oklahoma, United States
Digestive Disease Specialists Inc
🇺🇸Oklahoma City, Oklahoma, United States
Memorial Clinical Research
🇺🇸Oklahoma City, Oklahoma, United States
DiscoveResearch, Inc.
🇺🇸Beaumont, Texas, United States
ClinRx Research, LLC
🇺🇸Carrollton, Texas, United States
Rodriguez Clinical Trials
🇺🇸Houston, Texas, United States
Advanced Research Institute, Inc.
🇺🇸Ogden, Utah, United States
Clinical Trials of Texas, Inc.
🇺🇸San Antonio, Texas, United States
Centro de Investigaciones Medicas Mar del Plata SRL
🇦🇷Mar del Plata, Buenos Aires, Argentina
Instituto de Pesquisa Clinica em Campinas
🇧🇷Campinas, Sao Paulo, Brazil
CPQuali Pesquisa Clinica Ltda
🇧🇷Sao Paulo, Brazil
Diacon Hospital and research Center - Diabetology
🇮🇳Bengaluru, Karnataka, India
Synexus Stanza Clinical Research Centre
🇿🇦Pretoria, Gauteng, South Africa
Simon Williamson Clinic
🇺🇸Birmingham, Alabama, United States
Northwest Gastroenterology Clinic, LLC
🇺🇸Portland, Oregon, United States
Steno Diabetes Center Copenhagen
🇩🇰Hellerup, Copenhagen, Denmark
Gastroenheden, Hvidovre hospital
🇩🇰Hvidovre, København, Denmark
MAC Clinical Research Manchester
🇬🇧Manchester, Greater Manchester, United Kingdom
MAC Clinical Research, Monarch House
🇬🇧Leeds, West Yorkshire, United Kingdom
Mid Essex Hospital Services NHS Trust Broomfield Hospital
🇬🇧Chelmsford, United Kingdom
Arkansas Gastroenterology
🇺🇸North Little Rock, Arkansas, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
Medical Research Center of Connecticut, LLC
🇺🇸Hamden, Connecticut, United States
Clinical Trials of SWLA, LLC
🇺🇸Lake Charles, Louisiana, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Preferred Research Partners, Inc.
🇺🇸Little Rock, Arkansas, United States
Unity Health - Searcy Medical Center
🇺🇸Searcy, Arkansas, United States
Rocky Mountain Diabetes and Osteoporosis Center, PA
🇺🇸Idaho Falls, Idaho, United States
Clinical Research Institute of Michigan
🇺🇸Chesterfield, Michigan, United States
Gastroenterology Associates of Western Michigan, West Michigan Clinical Research Center
🇺🇸Wyoming, Michigan, United States
Synexus Clinical Research US, Inc
🇺🇸Anderson, South Carolina, United States
Clinical Research of South Nevada - CROSN
🇺🇸Las Vegas, Nevada, United States
CIDIM - Centro Integral de Diagnóstico por Imágenes Marchegian
🇦🇷Cordoba, Argentina
Privatklinik wehlre-Diakonissen
🇦🇹Salzburg, Austria
Oö. Gesundheits- und Spitals-AG/LKH Steyr
🇦🇹Steyr, Austria
AZ Sint Lucas Brugge
🇧🇪Brugge, West-Vlaanderen, Belgium
Carolina Medical Research
🇺🇸Clinton, South Carolina, United States
Synexus Clinical Research
🇺🇸Greer, South Carolina, United States
Instituto Medico Catamarca-I.ME.C
🇦🇷Rosario, Santa Fe, Argentina
Montana Medical Research
🇺🇸Missoula, Montana, United States
Avant Research Associates LLC
🇺🇸Crowley, Louisiana, United States
Diabetes and Endocrine Associates, P.C.
🇺🇸Omaha, Nebraska, United States
Clinical Trials of America, Inc.
🇺🇸West Monroe, Louisiana, United States
Aa Mrc, Llc
🇺🇸Flint, Michigan, United States
National Clinical, LLC
🇺🇸Hamtramck, Michigan, United States
Garden State Endocrinology LLC
🇺🇸Brick, New Jersey, United States
Excel Clinical Research
🇺🇸Las Vegas, Nevada, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
AGA Clinical Research Associates, LLC
🇺🇸Egg Harbor Township, New Jersey, United States
Digestive Disease Specialists
🇺🇸Las Vegas, Nevada, United States
Palm Research Center
🇺🇸Las Vegas, Nevada, United States
Universitair Ziekenhuis Antwerpen, Gastro-Enterologie,
🇧🇪Edegem, Antwerp, Belgium
East Tennessee Research Institute
🇺🇸Johnson City, Tennessee, United States
CIPREC
🇦🇷Buenos Aires, Ciudad Autonoma deBuenos Aires, Argentina
West Virginia University
🇺🇸Morgantown, West Virginia, United States
Instituto Catarinense de Endocrinologia e Diabetes (ICED)
🇧🇷Joinville, Santa Catarina, Brazil
Consultorios Asociados de Endocrinologia e Investigación Cl
🇦🇷Buenos Aires, Buenos Aires Province, Argentina
Hospital Sirio Libanes
🇦🇷Caba, Buenos Aires Province, Argentina
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Centro Universitario de Investigacion en Farmacologia Clinic
🇦🇷Corrientes, Argentina
Instituto Privado de Investigaciones Clinicas de Cordoba
🇦🇷Córdoba, Argentina
UMHAT - Kaspela- EOOD
🇧🇬Plovdiv, Bulgaria
VIVIT Institute, am LKH Feldkirch
🇦🇹Feldkirch, Vorarlberg, Austria
UZ Brussel
🇧🇪Jette, Brussel, Belgium
Recherche GCP Research
🇨🇦Montreal, Quebec, Canada
South Shore Medical Arts
🇨🇦Bridgewater, Nova Scotia, Canada
MHAT Yuliya Vrevska Byala
🇧🇬Byala, Ruse, Bulgaria
Medical Center Asklepion - Humane Medicine Research EOOD
🇧🇬Sofia, Bulgaria
Centro Cardiovascular y de Diabetes
🇨🇴Barranquilla, Atlantico, Colombia
Asociación Colombiana de Diabetes
🇨🇴Bogotá, Cundinamarca, Colombia
Endocare Ltda.
🇨🇴Bogotá, Distrito Capital De Bogotá, Colombia
Centro Cardiovascular Colombiano Clínica Santa María
🇨🇴Medellin, Antioquia, Colombia
University of Calgary
🇨🇦Calgary, Alberta, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Central Alberta Research Centre
🇨🇦Red Deer, Alberta, Canada
Patient research centre
🇨🇦St. John's, Newfoundland and Labrador, Canada
Healthy Medical Center
🇨🇴Zipaquira, Cundinamarca, Colombia
Kumudini Devi Diabetes Research Center; Ramdevrao Hospital
🇮🇳Hyderabad, Andhra Pradesh, India
IPS Centro Medico Julian Coronel S.A
🇨🇴Cali, Valle Del Cauca, Colombia
Rodrigo Botero S.A.S.
🇨🇴Medellín, Antioquia, Colombia
Fundación del Caribe para la InvestigacionBiomédica-Fundación BIOS
🇨🇴Barranquilla, Atlantico, Colombia
Medplus Centro de Recuperacion Integral S.A.S.
🇨🇴Bogotá, Distrito Capital, Colombia
M V Hospital & Research Centre
🇮🇳Lucknow, Uttar Pradesh, India
Lifecare Clinic and Research Centre - Internal Med/Diabetology
🇮🇳Bangalore, Karnataka, India
Centro de Investigaciones Clínicas IPS CARDIOMET Pereira
🇨🇴Pereira, Risaralda, Colombia
King George Hospital
🇮🇳Visakhapatnam, Andhra Pradesh, India
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegerszeg, Zala, Hungary
Bnei-Zion MC
🇮🇱Haifa, Israel
Polana-D
🇱🇻Daugavpils, Latvia
Pauls Stradins Clinical University Hospital, Endokrinologijas nodala
🇱🇻Riga, Latvia
Clinical Trial Unit, School of Medical Sciences, Health Campus, Hospital Universiti Sains Malaysia
🇲🇾Kubang Kerian, Malaysia
Centro Especializado en Diabetes, Obesidad y Prevencion de E - Endocrinology
🇲🇽Mexico, Distrito Federal, Mexico
Centro Medico Imbanaco de Cali S.A.
🇨🇴Cali, Valle Del Cauca, Colombia
Zydus Hospital
🇮🇳Ahmedabad, Gujarat, India
Klinische Forschung Dresden GmbH
🇩🇪Dresden, Saxony, Germany
Markhot Ferenc Oktatokorhaz es Rendelointezet
🇭🇺Eger, Heves, Hungary
Szegedi TudomanyegyetemSzent-Gyorgyi Albert Klinikai Kozpont és Altalanos Orvostudomanyi Kar Belgyogyaszati Klinika
🇭🇺Szeged, Hungary
Dr. Jivraj Mehta Smarak Health Foundation Bakeri Medical Research Centre - Gasterentrology
🇮🇳Ahmedabad, Gujarat, India
Strázsahegy Gyógyszertár Medicina
🇭🇺Budapest, Hungary
Victoria Hospital Bangalore Medical College and Research Institute
🇮🇳Bengaluru, Karnataka, India
Rajalakshmi Hospital
🇮🇳Bengaluru, Karnataka, India
Universal Hospital
🇮🇳Pune, Maharashtra, India
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
Cardinal Santos Medical Center
🇵🇭San Juan City, Metro Manila, Philippines
Manila Doctors Hospital, Ermita
🇵🇭Manila, Metropolitan Manila, Philippines
Saint-Petersburg City Pokrovskaya Hospital
🇷🇺St-Petersburg, Leningrad Region, Russian Federation
Sir Ganga Ram Hospital (SGRH)
🇮🇳Delhi, India
Vinaya Hospital & Research Centre
🇮🇳Mangalore, India
Kraslava Hospital
🇱🇻Kraslava, Kraslavas Nov., Latvia
Clinical Investigation Centre
🇲🇾Kuala Lumpur, Malaysia
Clinicos Asociados BOCM SC
🇲🇽Mexico, Distrito Federal, Mexico
Hospital Sultanah Bahiyah
🇲🇾Alor Setar, Kedah, Malaysia
Hospital Taiping
🇲🇾Taiping, Malaysia
Unidad de Investigación Clínica en Medicina S.C/
🇲🇽Guadalajara, Jalisco, Mexico
Mentrials Sa de Cv
🇲🇽Mexico DF, Distrito Federal, Mexico
Consultorio particular
🇲🇽Guadalajara, Jalisco, Mexico
Specjalistyczny Gabinet Neurologiczny Marta Banach
🇵🇱Kraków, Lesser Poland, Poland
Centrum Medyczne Lukamed
🇵🇱Chojnice, Poland
Changi General Hospital
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
Faculty of Medicine, Siriraj Hospital, Mahidol University
🇹🇭Bangkok, Thailand
Centro de Investigacion Cardiometabolica de Aguascalientes SA de CV
🇲🇽Aguascalientes, Mexico
Sociedad de Metabolismo y Corazon S.C.
🇲🇽Veracruz, Mexico
CIADEN (Centro de Investigación y Atención de Diabetes, Endocrinología y Nutrición)
🇲🇽Durango, Mexico
Regional Municipal noncommercial Enterprise "Chernivtsi Regional Endocrinology Center", Polyclinic department, Higher State Educational Establishment of Ukraine "Bukovinian State Medical University", Department of Clinical Immunology, Allergology and Endo
🇺🇦Chernivtsi, Ukraine
Communal Institution Kherson City Clinical Hospital
🇺🇦Kherson, Ukraine
Odessa Railway Clinical Hospital of Branch of HC JSC Ukrzaliznytsia, Odessa National Medical University
🇺🇦Odesa, Ukraine
Municipal Institution 6th City Clinical Hospital, Dept of Gastroenterology
🇺🇦Zaporizhzhia, Ukraine
West Visayas State University Medical Center
🇵🇭IloIlo City, IloIlo, Philippines
San Juan De Dios Educational Foundation, Inc.
🇵🇭Pasay, Metropolitan Manila, Philippines
Ospital ng Makati
🇵🇭Makati City, NCR, Philippines
GUZ Saratov City Clinical Hospital 9
🇷🇺Saratov, Saratov Region, Russian Federation
Perpetual Succor Hospital
🇵🇭Cebu City, Philippines
Rostov on Don
🇷🇺Rostov on Don, Russian Federation
National University Hospital
🇸🇬Singapore, Singapore
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Scientific Institute of Clinical and Experimental Lymphology
🇷🇺Novosibirsk, Russian Federation
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
State Institution Ukrainian State Research Institute of Medical and Social Problems of Disability of the Ministry of Health of Ukraine
🇺🇦Dnipro, Dnipropetrovs'ka Oblast', Ukraine
Municipal Institution, City Hospital #7, polyclinic department, c. Zaporizhzhia
🇺🇦Zaporizhzhia, Zaporizhzhia Region, Ukraine
Poltava Regional Clinical Hospital
🇺🇦Poltava, Ukraine
Royal Oldham Hospital
🇬🇧Oldham, Lancashire, United Kingdom
Chernivtsi Regional Clinical Hospital
🇺🇦Chernivtsi, Ukraine
Ivano-Frankivsk National Medical University
🇺🇦Ivano-Frankivsk, Ukraine
Ivano-Frankivsk Central City Clinical Hospital
🇺🇦Ivano-Frankivsk, Ukraine
Clinical Endocrinology of SI "V.Danilevsky Institute for endocrine pathology problems National Academy of Medical sciences of Ukraine"
🇺🇦Kharkiv, Ukraine
Municipal nonprofit entity of Kharkiv municipal council
🇺🇦Kharkiv, Ukraine
Kyiv Railway Clinical Hospital No-2 of Branch of Healthcare Center of the PJSC Ukrainian Railway , Endocrynology Department
🇺🇦Kyiv, Ukraine
Polyclinic of medical services and rehabilitation department of State Joint-Stock Holding Company Artem, day-patient unit
🇺🇦Kyiv, Ukraine
Private Small-Scale Enterprise Medical Centre Pulse
🇺🇦Vinnytsia, Ukraine
MAC Research, Exchange House
🇬🇧Cannock, Staffordshire, United Kingdom
University Hospitals of North Midlands
🇬🇧Stoke on Trent, Staffordshire, United Kingdom
Heartland Clinical Research, Inc
🇺🇸Omaha, Nebraska, United States
Toronto Digestive Disease Associates, Inc.
🇨🇦Vaughan, Ontario, Canada
Scentryphar Pesquisa Clínica Ltda
🇧🇷Campinas, Sao Paulo, Brazil
North Alabama Research Center, LLC
🇺🇸Athens, Alabama, United States
Klinische Forschung Karlsruhe GmbH
🇩🇪Karlsruhe, Baden-Wurttemberg, Germany
Options Health Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Hope Clinical Research
🇺🇸Canoga Park, California, United States
Torrance Clinical Research Institute, Inc.
🇺🇸Lomita, California, United States
GW Research Inc
🇺🇸Chula Vista, California, United States
Angel City Research Inc.
🇺🇸Los Angeles, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
New Hope Research Development
🇺🇸Whittier, California, United States
Innovative Research of West FL, Inc.
🇺🇸Clearwater, Florida, United States
Clinical Research of West Florida
🇺🇸Clearwater, Florida, United States
AMPM Research Clinic
🇺🇸Miami, Florida, United States
Summit Clinical Research, LLC.
🇺🇸Carnesville, Georgia, United States
iResearch Atlanta LLC
🇺🇸Decatur, Georgia, United States
Infinite Clinical Trials
🇺🇸Riverdale, Georgia, United States
North Shore University Health System
🇺🇸Evanston, Illinois, United States
Southwest Gastroenterology
🇺🇸Oak Lawn, Illinois, United States
The Ohio State University, Wexner Medical Center
🇺🇸Columbus, Ohio, United States
CIC America Clinical Inquest Center Ltd.
🇺🇸Dayton, Ohio, United States
Family Practice Center of Wadsworth, Inc.
🇺🇸Wadsworth, Ohio, United States
Family Medical Associates, Research Department
🇺🇸Levittown, Pennsylvania, United States
Baylor College of Medicine Medical Center
🇺🇸Houston, Texas, United States
Biopharma Informatic Inc., Research Center
🇺🇸Houston, Texas, United States
Sante Clinical Research
🇺🇸Kerrville, Texas, United States
Amir Hassan, MD, PA
🇺🇸Houston, Texas, United States
Sagact Pllc.
🇺🇸San Antonio, Texas, United States
Blue Ridge Medical Research
🇺🇸Lynchburg, Virginia, United States
Manassas Clinical Research Centre
🇺🇸Manassas, Virginia, United States
Washington Gastroenterology PLLC
🇺🇸Tacoma, Washington, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
ALL Medical Research, LLC
🇺🇸Cooper City, Florida, United States
Clinical Research Consultants of Atlanta
🇺🇸Suwanee, Georgia, United States
Dayton Gastroenterology,Inc.
🇺🇸Beavercreek, Ohio, United States
Preferred Primary Care Physicians
🇺🇸Uniontown, Pennsylvania, United States
Guthrie Clinical Research
🇺🇸Sayre, Pennsylvania, United States
Instituto de Estudos e Pesquisas Clinicas do Ceara IEP/CE - Oncology
🇧🇷Fortaleza, Brazil
Hospital Universitario Principe de Asturias
🇪🇸Madrid, Spain
University of Louisville
🇺🇸Louisville, Kentucky, United States
PMG Research of Winston-Salem, LLC
🇺🇸Winston-Salem, North Carolina, United States
The Center for Clinical Research
🇺🇸Winston-Salem, North Carolina, United States
VA Medical Center McGuire VAMC
🇺🇸Richmond, Virginia, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Clinical Trials of South Carolina
🇺🇸Charleston, South Carolina, United States
Centro de Desarrollo Biomédico S.C.P
🇲🇽Mérida, Yucatán, Mexico
Lovelace Scientific Resources, Inc.
🇺🇸Albuquerque, New Mexico, United States
CHEAR Center LLC
🇺🇸Bronx, New York, United States
Kovai Diabetes Speciality Centre
🇮🇳Coimbatore, Tamil Nadu, India
University of California San Diego
🇺🇸La Jolla, California, United States
Cumberland Research Associates, LLC
🇺🇸Fayetteville, North Carolina, United States
Unidad de Investigacion Clinica Cardiometabolica de Occidente
🇲🇽Guadalajara, Jalisco, Mexico
Instituto de Investigaciones Clinicas de Rosario
🇦🇷Rosario, Santa Fe, Argentina
Meridian Clinical Research, LLC
🇺🇸Rockville, Maryland, United States
FARMOVS
🇿🇦Bloemfontein, Free State, South Africa
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States