ACTRN12613000843752尚未招募4 期
In patients with type 2 diabetes as opposed to healthy volunteers, what will the GLP-1 release and expression of glucose sensing molecules be in functionally identified colonic cells, activated by glucose or glibenclamide
Dr. Nam Q Nguyen0 个研究点目标入组 40 人开始时间: 2013年7月31日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Patients with type 2 diabetes (World Health Organisation (WHO) criteria) managed by diet alone or metformin, with a HbA1c =/< 7.5%.
- •Healthy volunteers, matched as closely as possible to the diabetic subjects for age, sex, and body mass index.
排除标准
- •Significant illness other than diabetes, including impairment to cardiovascular or respiratory function that limits a subject’s activity and therefore would represent a risk to undertaking endoscopy safely (American Society of Anesthesiologists Grade 3 or more)
- •History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms (as assessed by a validated upper gastrointestinal symptom questionnaire, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
- •Haemoglobin below the lower limit of the normal range (ie. <135g/L for men and 115g/L for women), and ferritin below the lower limit of normal (ie. <10mcg/L)
- •Impaired renal or liver function (as assessed by calculated creatinine clearance < 90 mL/min or abnormal liver function tests (> 2 times upper limit of normal))
- •History of severe respiratory, cardiovascular, hepatic and/or renal disease, chronic alcohol abuse or epilepsy (excluded by history)
- •Subjects requiring medication that may influence gastrointestinal function
- •Any patient with coagulopathy.
- •Allergy to glibencamide and/or sulphonamide derivatives
- •Patients with Thrombocytopenia
- •Patients requiring treatment with anticoagulants, anti-platelet agents and NSAIDS
- •Presence of mucosal abnormalities at sigmoidoscopy such as inflammatory bowel disease and colorectal cancer.
- •Body mass index greater than 32 kg/m2
- •Evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes per day
- •Female patients not using appropriate contraceptive method (ie oral contraceptive pill, diaphragm, Depo-Provera hormonal contraceptive injection, intrauterine device (IUD), Norplant method)
- •Vegetarian, lactation, or pregnancy (verified by urine testing in women of reproductive age; in these subjects, the study will be completed during the follicular phase of the menstrual cycle)
- •Donation of blood within the previous 3 months
- •Participation in any other research studies within the previous 3 months
研究者
相似试验
已完成
不适用
EXERFLOW STUDY:The effects of aerobic and resistance exercise training on vascular endothelial function in people with type 2 diabetes mellitusType 2 diabetesVascular function (endothelial function)Metabolic and Endocrine - DiabetesCardiovascular - Diseases of the vasculature and circulation including the lymphatic systemACTRN12609000799257Baker IDI Heart and Diabetes Institute45
已完成
3 期
Double blind, randomised, comparative, multicentre, parallel-group study design to evaluate the effects of Pioglitazone on cardiovascular risk markers in type 2 diabetes mellitusACTRN12608000534381Takeda Italia Farmaceutici S.p.A.100
已完成
不适用
ovel Exercise Strategies for the Management of Type 2 DiabetesType 2 diabetesMetabolic and Endocrine - DiabetesCardiovascular - Diseases of the vasculature and circulation including the lymphatic systemCardiovascular diseaseACTRN12614001220651niversity of Sydney41
尚未招募
不适用
A Comparison of Peri-Operative and Post Acute Coronary Syndrome Glycaemic Control in Insulin Requiring Patients with Type 2 Diabetes at St Vincent’s Hospital With and Without Real-Time Continuous Glucose Monitoring.Type 2 diabetes requiring insulinAcute coronary syndromesPost - operative patientsMetabolic and Endocrine - DiabetesCardiovascular - Coronary heart diseaseSurgery - Surgical techniquesACTRN12608000125325St Vincent's Hospital60
招募中
不适用
Structured monitoring of blood glucose for people with non-insulin-treated type 2 diabetes: Structured Testing Program Implementation Trial – Updated Protocol (STeP IT UP)Type 2 diabetes mellitus (T2DM)Metabolic and Endocrine - DiabetesACTRN12613000927729Roche Diagnostics Australia145