In patients with type 2 diabetes mellitus who are sedentary, are aerobic exercise or resistance exercise, different to no exercise (stretching only) in causing change in endothelial function and insulin sensitivity?

Baker IDI Heart and Diabetes Institute0 sites45 target enrollmentSeptember 15, 2009

Overview

No summary available.

Registry

who.int

Start Date

September 15, 2009

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

Baker IDI Heart and Diabetes Institute

•People with established type 2 diabetes (duration \> 6 months), treated with diet or oral antihyperglycaemic agents, as monotherapy, dual or triple therapy with metformin, sitagliptin, glitazone or acarbose; (no more than 3 oral agents; stable dose for \= 8 weeks), with stable weight over the previous 3 months (\< 5% change in body weight), stable glycaemic control for at least the past 8 weeks (no changes to diabetes medication), HbA1c greater or equal to 6\.5% and less than or equal to 9\.9%.

•Exceeding the national recommendations for exercise which are at least 30 mins of moderate\-intensity aerobic activity on 5 days of the weeks for at least 3 months and/or at least 20 mins of vigorous\-intensity aerobic activity on 3 days of the week for at least 3 mths (60 mins per week). Any strength trainig for 2 or more sessions per week in last 3 months is an exclusion. Body mass index \<18\.0 or \>40\.0, seated resting blood pressure \> 160 mm Hg systolic of \> 95 mm Hg diastolic, pregnancy, anticipated requirement for medications affecting glucose tolerance during trial, renal disease or kidney failure, current smoker, taking medication to lower heart rate (beta blockers), unable to commit to completing the entire protocol, language other than English, known physical activity contraindications, other illness/injury (acute or chronic) leading to physical or medical problems that may limit the ability to perfom the necessary exercise.