Asymptomatic Carotid Surgery Trial 2: an international randomised trial to compare carotid endarterectomy with carotid artery stenting to prevent stroke

Not Applicable

Completed

• Conditions: Stroke caused by stenosis in the carotid arteries; Circulatory System; Stroke

• Registration Number: ISRCTN21144362
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

2009 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/19540137 protocol 2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24051108 results 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34469763/ (added 02/09/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-07-03
• Study Completion: 2019-12-31
• Last Update Posted: 13 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 3625

Inclusion Criteria

1. Patient in need of some type of carotid artery intervention, with substantial uncertainty about whether to treat with CEA or CAS
2. Carotid artery stenosis with no ipsilateral carotid territory symptoms within the last 6 months
3. Patient fit and willing for follow-up

Exclusion Criteria

1. Previous CEA or CAS in randomised artery
2. High risk of adverse events of trial treatment e.g. inaccessible stenosis
3. Small likelihood of worthwhile benefit e.g. low risk of stroke
4. Patient unable or unwilling to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Peri-procedural hazards (within 30 days) stroke, myocardial infarction and death<br> 2. Long-term hazards (after 30 days) stroke and death<br>

Secondary Outcome Measures

Name	Time	Method
Cost-effectivness of CEA and CAS