Asymptomatic Carotid Surgery Trial -2 (ACST-2). A randomised trial to compare CEA versus CAS to prevent stroke. - Asymptomatic carotid surgery trial - 2.

niversity of Oxford0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1.Unilateral or bilateral carotid artery stenosis appropriate for surgery or stenting
•2.patients'carotid stenosis has not caused symptoms for at least 6 months
•3. the patient is fit for, and willing to have carotid surgery or stenting and accessible for follow-up, with no knwon illness preventing long-term follow-up.
•4. there is substantial uncertainty about whether the patient is better by surgery or stenting.

•Reasons for not entering patients into the trial are specified by the responsible collaborator, not by the protocol, but include:
•1) a small likelihood of worthwhile benefit such as low risk of cerebral infarction from a smooth calcified carotid plaque not causing significant stenosis or some major life threatening disease other than stroke.
•2) a high risk of adverse effects of trial treatment such as recent acute myocardial infacrtion or intracerebral neoplasia or aneurysm.
•3)those found unsuitable for stenting or surgery after angiography (e.g. because the lesion is surgically inaccessible or because the aortic arch anatomy is difficult for stenting access).
•4)re-narrowing of the artery following previous CEA or stent.
•5) patients with a likely cardiac source of emboli
•6)patients unable or unwilling to give informed consent.

发起方