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Clinical Trials/NL-OMON47429
NL-OMON47429
Recruiting
Phase 4

Asymptomatic Carotid Surgery Trial -2 (ACST-2). A randomised trial to compare CEA versus CAS to prevent stroke. - Asymptomatic carotid surgery trial - 2.

niversity of Oxford0 sites100 target enrollmentTBD
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Conditionscarotid artery stenosiscarotid plaque10011954

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
carotid artery stenosis
Sponsor
niversity of Oxford
Enrollment
100
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •1\.Unilateral or bilateral carotid artery stenosis appropriate for surgery or stenting
  • •2\.patients'carotid stenosis has not caused symptoms for at least 6 months
  • •3\. the patient is fit for, and willing to have carotid surgery or stenting and accessible for follow\-up, with no knwon illness preventing long\-term follow\-up.
  • •4\. there is substantial uncertainty about whether the patient is better by surgery or stenting.

Exclusion Criteria

  • •Reasons for not entering patients into the trial are specified by the responsible collaborator, not by the protocol, but include:
  • •1\) a small likelihood of worthwhile benefit such as low risk of cerebral infarction from a smooth calcified carotid plaque not causing significant stenosis or some major life threatening disease other than stroke.
  • •2\) a high risk of adverse effects of trial treatment such as recent acute myocardial infacrtion or intracerebral neoplasia or aneurysm.
  • •3\)those found unsuitable for stenting or surgery after angiography (e.g. because the lesion is surgically inaccessible or because the aortic arch anatomy is difficult for stenting access).
  • •4\)re\-narrowing of the artery following previous CEA or stent.
  • •5\) patients with a likely cardiac source of emboli
  • •6\)patients unable or unwilling to give informed consent.

Outcomes

Primary Outcomes

Not specified

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