Cognitive Rehabilitation for Attention and Memory for people with Multiple Sclerosis (CRAMMS): a pragmatic randomised controlled trial

niversity of Nottingham (UK)0 sites449 target enrollmentAugust 14, 2014

Overview

Registry

who.int

Start Date

August 14, 2014

End Date

August 31, 2018

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Nottingham (UK)

•1\. Are 18 or over and under 70 years of age. The lower age limit is because MS is usually diagnosed in adulthood and treatment strategies tend to be different for children. People aged 70 and over may start to encounter age\-related cognitive problems, which may confound the effects of cognitive problem due to MS. Also, most tests are standardised on this adult age group.
•2\. Have relapsing or progressive MS, diagnosed at least 3 months prior to the baseline assessment contact with the study team, to allow for adjustment to diagnosis. Report having cognitive problems as determined by a cut\-off score of \>27 on the patient version of the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ). This cut\-off is based on previous research and is two standard deviations below the mean for healthy participants.
•3\. Have cognitive deficits, defined as performance below the 25th percentile on the Brief Repeatable Battery of Neuropsychological Tests (BRBN).
•4\. Are able to travel to one of the centres and attend group sessions.
•5\. Are able to speak English sufficiently to complete the cognitive assessments and take part in group sessions.
•6\. Give informed consent.

•1\. Vision or hearing problems, such that they are unable to complete the cognitive assessments, judged by assessor.
•2\. Have concurrent severe medical or psychiatric conditions which would prevent participants from engaging in treatment, if allocated.
•3\. Are involved in other psychological intervention trials.