The ALMASED Concept against Overweight and Obesity and Related Health Risk (ACOORH),Evaluation of Almased on body composition and co-morbidities in non-diabetic, viscerally fat-distributed overweight or obese patients with at least one additional co-morbidity and with a special focus on the pre-diabetic state. - ACOORH

Inst, f. Sport u. Sportwisenschaftder Universität Freiburg0 个研究点目标入组 463 人开始时间: 2014年10月14日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Age: 21-65 years
•waist circumference = 102cm for males and = 88 cm for females
•BMI 27-35 kg/m2
•with at least one additional co-morbidity of the metabolic syndrome:
•- fasting blood glucose of 100-126 mg/dl
•- and/or triglycerides of 150-400 mg/dl
•- and/or low HDL cholesterol (<40 mg/dl)
•- and/or hypertension (anti-hypertensive therapy or untreated systolic blood pressure of 140-160 and/or diastolic blood pressure of 90-100 mmHg)
•Willingness to participate: Participants must be willing to be randomized to either Almased or the Lifestyle Intervention and to follow the protocol to which they have been assigned.

•- Inability to be physically moderately active due to illness (e.g., chronic heart disease, arrhythmia or heart rate at rest >100/min, valvular heart disease, arthritis of larger joints, etc.)
•- Inability to perform physical exercise according to AHA/ACSM criteria
•- Total body weight > 141 kg
•- Impaired motor skills and / or load-bearing capacity of the supporting and musculoskeletal system
•- Severe (rest) hypertension (RRsyst >165 and / or RRdiast >115 mmHg)
•- Presence of diabetes mellitus type 1
•- Presence of diabetes mellitus type 2 (HbA1c > 6.5%)
•- Chronic renal failure (dialysis patient or creatinine >1.4 or 1.5 mg/dL (m/f)
•- Increasing liver function enzymes (ALT or gamma-GT) by more than threefold
•- Appetite suppressants, slimming, eating disorder
•- Psychiatric disorders with permanent medical supervision
•- Currently pregnant or nursing
•- Symptoms’ free malignant intervals less than 5 years

发起方

Inst, f. Sport u. Sportwisenschaftder Universität Freiburg