NCT01085019已完成不适用
Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 224
- 试验地点
- 4
- 主要终点
- Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone)
研究概览
简要总结
The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.
详细描述
The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 40-70 yrs
- •Men and postmenopausal women
- •Waist girth >102cm (men) or >88cm (women)
- •LDL-C > 2.8 mmol/L
- •Framingham 10-yr risk score < 10%
- •Marginal endothelial dysfunction
- •Non smoker
排除标准
- •Medication for lipid, hypertension, diabetes
- •History of CVD, diabetes, other endocrines disorders
- •Pre-menopausal women
- •Alcohol consumption > 1 drink per day
- •Unusual dietary habits (e.g. vegetarism)
- •Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
- •Aversion or intolerance for spices and/or herbs
- •Injury to fingers or amrs that would interfere with endothelial function measurement
研究组 & 干预措施
Dietary supplement: Placebo
Placebo Comparator
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone)
时间窗: at week 0 and week 4
次要结局
- Endothelial activation and inflammatory markers(at week 0 and week 4)
- Circulating level of plasma lipoproteins-lipids(at week 0 and week 4)
- Oxidative stress(at week 0 and week 4)
研究者
Charles Couillard
Professor
Laval University
研究点 (4)
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