Impact of Spices and Herbs on Endothelial Function

Not Applicable

Completed

• Conditions: Endothelial Function

• Registration Number: NCT01085019
• Lead Sponsor: Laval University

Brief Summary

The general objective of the study is to investigate the effects of the daily consumption of spices and herbs for four (4) consecutive weeks in endothelial function and cardiovascular risk factors of men and postmenopausal women.

Detailed Description

The purpose is to assess whether the polyphenol/antioxidant content of different spices will affect endothelial function and other cardiovascular risk factors.

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-03-09
• Study First Submitted QC: 2010-03-09
• Study First Posted: 2010-03-11
• Primary Completion: 2011-06
• Study Completion: 2011-12
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-26
• Last Update Posted: 2012-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

• Age 40-70 yrs
• Men and postmenopausal women
• Waist girth >102cm (men) or >88cm (women)
• LDL-C > 2.8 mmol/L
• Framingham 10-yr risk score < 10%
• Marginal endothelial dysfunction
• Non smoker

Exclusion Criteria

• Medication for lipid, hypertension, diabetes
• History of CVD, diabetes, other endocrines disorders
• Pre-menopausal women
• Alcohol consumption > 1 drink per day
• Unusual dietary habits (e.g. vegetarism)
• Chronic use of supplements (estrogens, vitamins, minerals or flavonoids)
• Aversion or intolerance for spices and/or herbs
• Injury to fingers or amrs that would interfere with endothelial function measurement

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone)	at week 0 and week 4

Secondary Outcome Measures

Name	Time	Method
Endothelial activation and inflammatory markers	at week 0 and week 4
Circulating level of plasma lipoproteins-lipids	at week 0 and week 4
Oxidative stress	at week 0 and week 4

Trial Locations

Locations (2)

Richardson Centre of Functional Foods and Nutracuticals; 🇨🇦 Winnipeg, Manitoba, Canada

Institute of Nutraceuticals and Functional Foods; 🇨🇦 Quebec City, Quebec, Canada