Effects of dialysis duration on brain perfusion and cognitive function in end-stage renal disease - short vs. long hemodialysis

Completed

Conditions: cerebral perfusion
cognitive function
Endstage renal disease
renal failure
10009841
10038430

Registration Number: NL-OMON49428

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

- Conventional HD (for part A): Treatment with conventional HD 3 times per week
4 hours
- Nocturnal HD (for part B): Treatment with nocturnal HD 3 times per week 8
hours
- Age >18 years
- Presence of a well-functioning central venous catheter or AV fistula or graft
with a vascular access flow of >400 mL/min

Exclusion Criteria

- Unable to obtain an optimal transcranial acoustic window during dialysis
- Severe cognitive impairment
- Medical history of (major) psychiatric illness, such as psychosis,
schizophrenia, severe personality disorder or depression with vital signs, that
could affect cognitive performance
- Non-adherence to the dialysis procedure
- Insufficient proficiency in the Dutch Language

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of the study is the difference in intradialytic<br /><br>cerebrovascular hemodynamic changes (cerebral blood flow velocity) between the<br /><br>longer HD (extended HD and NHD; 8 hours) vs. CHD session.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes of the study are the differences between the longer HD vs.<br /><br>CHD sessions regarding the following parameters:<br /><br>-Systemic hemodynamic changes (heart rate, stroke volume, cardiac output and BP)<br /><br>-Cognitive function<br /><br>-Cerebrovascular autoregulatory capacity<br /><br>-BP variability, i.e. baroreflex sensitivity (very short-term BP variability),<br /><br>standard deviation and coefficient of variation of the NIBP values (short-term<br /><br>BP variability; only for part A)<br /><br>-Cardiovascular autonomic (parasympathetic and sympathetic) function</p><br>