Cerebral Blood Flow during hemodialysis. A [15O]H2O PET-CT pilot study comparing cerebral blood flow before, during and after hemodialysis

Completed

Conditions: blood supply to the brain
10042258
10038430

Registration Number: NL-OMON42190

Lead Sponsor: Interne geneeskunde, Nefrologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

Patients aged 65 years or older on maintenance hemodialysis, of which at least 6 patients for a longer period of time (>1years). The patients must have an arteriovenous fistula without recirculation as established by routine Transonic flow measurements. The hemoglobin value should be in the target range 6.2- 8 mmol/l since at least 1 month.

Exclusion Criteria

1. The absence of informed consent. 2. Diagnosis of dementia, hydrocephalus, history of raised intracranial pressure, significant (>70%) carotid artery stenosis, end stage liver disease. 3. Actively treated cancer. 4. Actual hospital admission at timing of HD study session. 5. Cochlear implants. 6. Claustrophobia. 7. MRI incompatible implants in the body (including prosthetic heart valves). 8 Pacemakers. 9. Subcutaneous insulin infusion pomp. 10. Any risk of having metal particles in the eyes due to manual work without proper eye protections. 11. Tatoos containing red pigments that form a safety risk. 12. The refusal to be informed of significant carotid artery stenosis (duplex) or structural brain abnormalities (MRI) that could be detected during the study.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. the change in total and regional CBF during the study session as assessed by<br /><br>PET-CT scan.<br /><br>2. the change in rSO2 during the study session as assessed by NIRS, and it's<br /><br>correlation with the PET-CT scan estimates</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Change in regional and total CBF correlated to<br /><br>a. structural cerebral lesions on MRI (e.g. white matter lesions)<br /><br>b. outcomes of cognitive testing.</p><br>