Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 996
- 主要终点
- Postoperative recurrence of liver cancer
研究概览
简要总结
Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time.
排除标准
- •Pediatric transplants
- •Re-transplants
- •Multi-organ transplants
- •Liver cancer patients with macrovascular invasion or distant metastasis
- •Patients who died within 30 days after transplantation
结局指标
主要结局
Postoperative recurrence of liver cancer
时间窗: 2015.1.1-2022.12.31
Postoperative mortality
时间窗: 2015.1.1-2022.12.31
次要结局
未报告次要终点
研究者
Xiao Xu
Professor
Zhejiang University