Very low dose of lidocaine attenuates fentanyl induced cough: A double blind randomized controlled trial
Phase 2
Completed
- Conditions
- Fentanyl-induced cough is commonly occurred, especially in pre anesthetic induction between 18% and 65% and lidocaine can alleviate the incidence and severity of cough. Therefore, the objective of the present study was to demonstrate efficacy of low dosage of lidocaine attenuate FICCough, Fenanyl, Lidocaine, low dose
- Registration Number
- TCTR20191207001
- Lead Sponsor
- Phramongkutklao Hospital and Collage of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 320
Inclusion Criteria
ASA class 1-2
Exclusion Criteria
Patients were unwilling to participate, had a history of allergy to lidocaine or fentanyl, history of chronic obstructive pulmonary disease, bronchial asthma, recent respiratory tract infection less than 2 weeks, impaired kidney or liver function, or had been treated with angiotensin converting enzyme inhibitors or beta blocker, symptomatic bradycardia, tachyarrhythmia, left bundle branch block and second or third-degree atrioventricular block, pregnancy and language barrier.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of cough 3 minutes after fentanyl injection Incidence of cough
- Secondary Outcome Measures
Name Time Method Severity of cough 3 minutes after fentanyl injection The number of episodes of cough (mild,moderate,severe),Risk factor of cough 3 minutes after fentanyl injection Identified risk from all data variables,Hemodynamic response 3 minutes before fentanyl injection (baseline) and at 3 minutes after starting fentanyl injections NIBP,EKG,SpO2 was measured