Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Preventing SSIs in a CABG (coronary artery bypass grafting) population.
研究概览
简要总结
A randomized controlled trial on adults who underwent coronary artery bypass grafting (CABG) surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing surgical site infection in the CABG population.
Eligible patients will be randomized using a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardiothoracic ICU-admitted patients who underwent CABG on CPB.
排除标准
- •Patients who require reoperation within 30 days.
- •Immunosuppressant patients.
- •Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively.
- •Pregnancy or breastfeeding.
- •Patients who refused to sign the informed consent.
研究组 & 干预措施
Intermittent (INT) cefazolin
干预措施: Cefazolin 2 GM Injection (Drug)
Intraoperative continuous infusion (CI) of cefazolin
干预措施: Cefazolin 2 g Infusion (Drug)
结局指标
主要结局
Preventing SSIs in a CABG (coronary artery bypass grafting) population.
时间窗: 3 months after surgery
次要结局
未报告次要终点
研究者
Hebatallah Ali Abdeen
Principal Investigator
Helwan University