A registry study on optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) biomarkers in retinal diseases

Recruiting

• Conditions: H35; H35.3; Other retinal disorders; Degeneration of macula and posterior pole

• Registration Number: DRKS00024399
• Lead Sponsor: Augenklinik des Universitätsklinikums Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

for Treatment Group: retinal disease that requires intravitreal anti-VEGF or steroid therapy

for Control Group: no specific inclusion criteria expect a healthy retina

Exclusion Criteria

inability to consent, history of retinal surgery, macular holes, amblyopia, media opacities that compromises the Image Quality (i.e. scarring in the central part of the Cornea), uncontrolled glaucoma, refraction error > 6diotre (spherical equivalent), best corrected visual acuity below 0,05

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary endpoint is the yearly change of morphological Parameter (i.e. vessel Density or retina thickness) in arm 1 and 2 (up to fifth year after start of treatment).<br>OCT(A) from the first visit will be compared to OCT(A) from every following yearly visits.

Secondary Outcome Measures

Name	Time	Method
secondary endpoint is of functional nature, i.e. the best corrected visual acuity after 1 year in arm 1 and 2.<br>Visual acuity from first visit will be compared to visual acuity from 1-year visit.